Ethopabate (HCID 6034)

개요

Ethopabate is an amidobenzoic acid.

이름 및 식별자

우선 이름: Ethopabate
IUPAC: methyl 4-acetamido-2-ethoxybenzoate
영어명: Ethopabate
분자식: C12H15NO4
분자량: 237.25

이름 및 동의어

ETHOPABATEMethyl 4-acetamido-2-ethoxybenzoate59-06-3Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl esterDTXSID6046264DTXCID4026264F4X3L6068ORefChem:58641200-414-3MFCD00075809Methyl 4-(acetylamino)-2-ethoxybenzoateAmprol Plus (veterinary)

이름 더 보기

4-Acetamido-2-ethoxybenzoic acid, methyl esterEthopatateEthytpatateIsovaleraldehvdeEthopabate (125 mg)Ethopabate, Vetranal

ETHOPABATE [MI]NCGC00160624-01CHEBI:183844ETHOPABATE [USP MONOGRAPH]Ethyl PabateMethyl 4-acetamido-2-ethoxy-benzoateNCGC00160624-04Ethopabat

데이터베이스 식별자

CAS: 59-06-3
PubChem CID: 6034
DTXSID: DTXSID6046264
ChEMBL: CHEMBL458769
ChEBI: CHEBI:183844
UNII: F4X3L6068O
EC Number: 200-414-3
Nikkaji: J4.596I

물성

구조 계산 물성

XLogP: 1.2
극성 표면적: 64.6 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 4
회전 가능 결합 수: 5
무거운 원자 수: 17
형식 전하: 0
복잡도: 280

실험 및 물리화학적 성질

Animal Drugs · 2건

Active Ingredients (Ethopabate) -> FDA Greenbook

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

물리화학적 성질

녹는점: 148 · 148-151 °C
끓는 점: 426.1 · 426.1±35.0 °C(Predicted)
밀도: 1.18 · 1.180±0.06 g/cm3(Predicted)
저장 조건: Sealed in dry,Room Temperature
용해도: 50 mg/mL · DMSO: 50 mg/mL (210.75 mM)
물리적 상태: 고체
산도 계수 (pKa): 14.12 · 14.12±0.70(Predicted)
색상: White to off-white
Merck: 13 · 13,3781
주요 응용: 법의학 및 독성학의약품(소분자)
InChI: InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)
InChIKey: GOVWOKSKFSBNGD-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC
EPA: Ethopabate (59-06-3)

화학적 성질

White to Off-White Solid

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.

Warning

H302 (95.8%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory InformationChemical: Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl ester

Hazard Classes and CategoriesAcute Tox. 4 (95.8%)

안전 데이터

wgk: 3
HS 번호: 2924296000
risk_code: 22
hazard_code: Xn
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

ATC CodeQP - Antiparasitic products, insecticides and repellents

MeSH Pharmacological ClassificationAgents useful in the treatment or prevention of COCCIDIOSIS in man or animals.

용도 및 제조

Use Classification · 2건

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

응용 분야 · 2건

개요Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.

용도A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.