3′,5′-사이클릭아데닐산
Camp
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기본 정보
- CAS
60-92-4- 표준 SMILES
Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1O- InChIKey
IVOMOUWHDPKRLL-KQYNXXCUSA-N- 분자식
- C10H12N5O6P
- 평균 분자량
- 329.21 g/mol
- 단동위원소 질량
- 329.05251973
개요
3',5'-cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. It has a role as a mouse metabolite, an Escherichia coli metabolite and a human metabolite. It is a 3',5'-cyclic purine nucleotide and an adenyl ribonucleotide. It is a conjugate acid of a 3',5'-cyclic AMP(1-).
이름 및 식별자
- 우선 이름
- Camp
- IUPAC
- (4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
- 현지명
- 3′,5′-사이클릭아데닐산
- 영어명
- Cyclic AMP
- 분자식
- C10H12N5O6P
- 분자량
- 329.21
이름 및 동의어
Cyclic AMPcAMP60-92-4Adenosine 3',5'-cyclic monophosphate3',5'-cyclic AMPAdenosine 3',5'-cyclophosphatecyclic 3',5'-AMPAdenosine 3',5'-phosphateCyclic Adenosine MonophosphateAdenosine cyclic monophosphatecyclic 3',5'-Adenylic acidAdenosine 3',5'-monophosphate
이름 더 보기
3′,5′-사이클릭아데닐산아데노신사이클릭포스페이트ADENOSINE CYCLOPHOSPHATEAcrasinADENOSINE CYCLPHOSPHATE(4aR,6R,7R,7aS)-6-(6-Amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxideMRD40C13orf83:5-CAMPKIAA1802
cyclic Adenosine 3',5'-phosphateAdenosine cyclic 3',5'-monophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)Adenosine 3',5'-cyclic phosphate3',5'-AMPAdenosine cyclic 3',5'-phosphateAdenosine cyclic phosphateCyclic adenylic acid
물성
구조 계산 물성보충 중
- XLogP
- -2.6
- 극성 표면적
- 155 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 10
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 498
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
CosmeticsSkin conditioning
LogP-2.96
Solubility4 mg/mL
Melting Point
219-220 °C
219 - 220 °C
Physical DescriptionSolid
Collision Cross Section
176.8 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
172 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine]
175.07 Ų [M-H]- [CCS Type: DT; Method: stepped-field]
188.8 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
181.3 Ų [M+Na]+
물리화학적 성질
- 녹는점
- 260 °C · 260 °C (dec.)(lit.)
- 끓는 점
- 56.12 °C · 56.12°C
- 밀도
- 2.47 · 2.47±0.1 g/cm3(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 33.3% (2 of 6) of reports.
Danger
H314 (16.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: Adenosine, cyclic 3',5'-(hydrogen phosphate)
Adenosine, cyclic 3',5'-(hydrogen phosphate): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Adenosine, cyclic 3',5'-(hydrogen phosphate): Environment tier I assessment
Hazard Classes and CategoriesSkin Corr. 1B (16.7%)
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- AU7357600
- 독성
- oms-hmn:oth 100 mmol/L JIDEAE 65,52,75
- HS 번호
- 29349990
- risk_code
- 34-36/37/38
- hazard_code
- C,Xi
- safety_code
- 22-24/25-45-36/37/39-26-36
화학 및 산업
약리 정보
Tissue LocationsAll Tissues
Cellular LocationsCytoplasm
Metabolite PathwaysAdenine phosphoribosyltransferase deficiency (APRT)
용도 및 제조
Household ProductsInformation on 1 consumer products that contain cyclic AMP (adenosine cyclic phosphate) in the following categories is provided:
Use ClassificationCosmetics -> Skin conditioning
General Manufacturing InformationAdenosine, cyclic 3',5'-(hydrogen phosphate): ACTIVE
응용 분야
용도cAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3': 5'-cyclic monophosphate. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate.
일반 설명Cyclic AMP is a second messenger molecule comprised of an adenine ribonucleotide bearing a phosphate group bound to the oxygen molecules at the 3' and 5' positions of the sugar moiety. Cyclic AMP, which is synthesized from ATP by the intracellular enzyme adenylate cyclase, modulates the activity of several hormone-dependent signal transduction pathways.
상·하류 제품 정보
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