Camp (HCID 6076)｜Huagongshe

개요

3',5'-cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. It has a role as a mouse metabolite, an Escherichia coli metabolite and a human metabolite. It is a 3',5'-cyclic purine nucleotide and an adenyl ribonucleotide. It is a conjugate acid of a 3',5'-cyclic AMP(1-).

이름 및 식별자

우선 이름: Camp
IUPAC: (4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
현지명: 3′,5′-사이클릭아데닐산
영어명: Cyclic AMP
분자식: C10H12N5O6P
분자량: 329.21

이름 및 동의어

Cyclic AMPcAMP60-92-4Adenosine 3',5'-cyclic monophosphate3',5'-cyclic AMPAdenosine 3',5'-cyclophosphatecyclic 3',5'-AMPAdenosine 3',5'-phosphateCyclic Adenosine MonophosphateAdenosine cyclic monophosphatecyclic 3',5'-Adenylic acidAdenosine 3',5'-monophosphate

이름 더 보기

3′,5′-사이클릭아데닐산아데노신사이클릭포스페이트ADENOSINE CYCLOPHOSPHATEAcrasinADENOSINE CYCLPHOSPHATE(4aR,6R,7R,7aS)-6-(6-Amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxideMRD40C13orf83:5-CAMPKIAA1802

cyclic Adenosine 3',5'-phosphateAdenosine cyclic 3',5'-monophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)Adenosine 3',5'-cyclic phosphate3',5'-AMPAdenosine cyclic 3',5'-phosphateAdenosine cyclic phosphateCyclic adenylic acid

데이터베이스 식별자

CAS: 60-92-4
PubChem CID: 6076
DTXSID: DTXSID8040436
ChEMBL: CHEMBL316966
ChEBI: CHEBI:17489
UNII: E0399OZS9N
EC Number: 200-492-9
Nikkaji: J4.811I

물성

구조 계산 물성

XLogP: -2.6
극성 표면적: 155 Å²
수소 결합 공여자 수: 3
수소 결합 수용자 수: 10
회전 가능 결합 수: 1
무거운 원자 수: 22
형식 전하: 0
복잡도: 498

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15

CosmeticsSkin conditioning

LogP-2.96

Solubility4 mg/mL

Melting Point · 2건

219-220 °C

219 - 220 °C

Physical DescriptionSolid

물리화학적 성질

녹는점: 260 °C · 260 °C (dec.)(lit.)
끓는 점: 56.12 °C · 56.12°C
밀도: 2.47 · 2.47±0.1 g/cm3(Predicted)
저장 조건: -20 °C · -20°C
용해도: 2 O: · H2O: 10 mg/mL 수용액의 pH는 대략입니다. 3.0. 나트륨염(A6885)은 약 20×입니다.
산도 계수 (pKa): 1 · 1.00±0.60(Predicted)
물리적 상태: 가루
색상: 하얀색
생물학적 소스: mouse
수용성: 50 mg/mL · 50mg/mL
Merck: 14 · 14,2708
BRN: 52645 · 52645
안정성: 흡습성
화장품 원료 기능: 피부 컨디셔닝
InChI: 1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKey: IVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES: Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
NIST: 3 · Adenosine 3',5'-cyclic monophosphate(60-92-4)
EPA: 3 · Adenosine, cyclic 3',5'-(hydrogen phosphate) (60-92-4)

화학적 성질

White crystalline or Pale yellow powder; odorless. Slightly soluble in water, almost insoluble in ethanol or ether.

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 33.3% (2 of 6) of reports.

Danger

H314 (16.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Chemical: Adenosine, cyclic 3',5'-(hydrogen phosphate)

Adenosine, cyclic 3',5'-(hydrogen phosphate): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Adenosine, cyclic 3',5'-(hydrogen phosphate): Environment tier I assessment

Hazard Classes and CategoriesSkin Corr. 1B (16.7%)

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: AU7357600
독성: oms-hmn:oth 100 mmol/L JIDEAE 65,52,75
HS 번호: 29349990
risk_code: 34-36/37/38
hazard_code: C,Xi
safety_code: 22-24/25-45-36/37/39-26-36
F 고인화성물질: 10-21
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

Tissue LocationsAll Tissues

Cellular LocationsCytoplasm

Metabolite PathwaysAdenine phosphoribosyltransferase deficiency (APRT)

용도 및 제조

Household ProductsInformation on 1 consumer products that contain cyclic AMP (adenosine cyclic phosphate) in the following categories is provided:

Use ClassificationCosmetics -> Skin conditioning

General Manufacturing InformationAdenosine, cyclic 3',5'-(hydrogen phosphate): ACTIVE

응용 분야 · 2건

용도cAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3': 5'-cyclic monophosphate. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate.

일반 설명Cyclic AMP is a second messenger molecule comprised of an adenine ribonucleotide bearing a phosphate group bound to the oxygen molecules at the 3' and 5' positions of the sugar moiety. Cyclic AMP, which is synthesized from ATP by the intracellular enzyme adenylate cyclase, modulates the activity of several hormone-dependent signal transduction pathways.

상·하류 제품 정보

상류 원료

하류 제품

6-티오구아닌 이노신-3',5'-사이클릭인산염

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

추가 설명 · 1건

정의ChEBI: Cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an adenyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic AMP(1-).