테트라소듐2-[2-(비스(카르복실레이토메틸)아미노)에틸-(카르복실레이토메틸)아미노]아세테이트

6.9 lb/gal /Apparent density/

Relative density (water = 1): 0.7

Slightly soluble in ethanol

Less soluble in alcohol than the potassium salt

Freely soluble in water

In water, 500 g/L at 20 °C

Solubility in water, g/100ml at 20 °C: 100-110

When heated to decomposition it emits toxic fumes of /nitrogen oxides and sodium oxides/

>200 °C

Liquid; Other Solid; Liquid; CBI; Dry Powder; Wet Solid; Large Crystals; Other Solid; Dry Powder

White solid; [Hawley] Colorless solid; [ICSC] White, slightly yellow, or cream-colored solid; Hygroscopic; [CHEMINFO]

COLOURLESS CRYSTALLINE POWDER.

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]；H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501 (click each P-code to see the statement)

Danger

Chemical: Glycine, N,N′-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4)

Chemical: Glycine, N,N′-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:?)

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14817

Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15231；Status: Active Update: 21-01-2015 https://echa.europa.eu/registration-dossier/-/registered-dossier/6906

Tetrasodium EDTA: Does not have an individual approval but may be used under an appropriate group standard

IMAP assessments - Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt: Human health tier I assessment

IMAP assessments - Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt: Human health tier I assessment

An eye irritant; [ICSC] Irritating to eyes but not skin of rabbits; Causes tetanic convulsions and death in rabbits and mice (acute exposure, route not specified); Emergency treatment: Symptomatic drug ingestion; [HSDB] May cause serious eye injury; [eChemPortal: ESIS] Not sensitizing to guinea pig skin; [IUCLID] A moderate skin and eye irritant; Causes changes in tubules (including acute renal failure and necrosis) in intraperitoneal lethal-dose studies of mice; [RTECS] Causes no to mild skin irritation and severe eye irritation; Weak skin sensitizer in one animal study, but considered non-sensitizing to human skin (two single cases reported over decades of heavy use in industrial and consumer products); Not mutagenic or potentially carcinogenic for humans; No effects on fertility in studies of rodents; Fetotoxic and teratogenic effects in experimental animals at very high doses (maternally toxic and possibly attributable to zinc deficiency); [EC] See Edetic acid.

Residues of ethylenediaminetetraacetic acid, tetrasodium salt are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: sequestrant. Limit: 5% of pesticide formulation.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), tetrasodium salt is included on this list.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), tetrasodium salt is included on this list.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Tetrasodium ethylenediaminetetraacetate is found on List D. Case No: 4036; Pesticide type: insecticide, fungicide, herbicide, antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): tetrasodium ethylenediaminetetraacetate; AI Status: Registrants of the pesticide have not made or honored a commitment to seek reregistration, conduct the necessary studies, or pay the requisite fees, or they have asked EPA to cancel their product registrations. Unless some other interested party supports them, products containing the pesticide will be cancelled.

Acute Tox. 4 (> 99.9%)；Eye Dam. 1 (> 99.9%)；Acute Tox. 4 (26.9%)；STOT RE 2 (12.8%)

Acute Tox. 4 (58.1%)；Skin Irrit. 2 (58.1%)；Eye Irrit. 2 (60.8%)；Acute Tox. 4 (29.4%)；STOT SE 3 (56.3%)；STOT RE 2 (25.3%)

Acute toxicity - category 4；Eye damage - category 1；Specific target organ toxicity (single exposure) - category 3

Acute toxicity (Oral) - Category 4；Serious eye damage/eye irritation - Category 2A；Specific target organ toxicity - Single exposure - Category 2 (systemic toxicity)；Hazardous to the aquatic environment (Acute) - Category 2

Serious eye damage/eye irritation - Category 2A

Acute Tox. 4 *；Eye Dam. 1

Incompatible with strong acids, nitrates, oxidizers. Can solubilize metals.

Reacts with most divalent and trivalent metallic ions forming soluble metal chelates.

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Tetracycline-HCl absorption in man, given concomitantly with tetra-Na EDTA and milk, showed inhibitory effect of milk counteracted by simultaneous ingestion of EDTA.

Cortisol reduced degree of vascular damage to adrenalectomized rat irrigated with Na4-EDTA salt if administered within 1-6 hr prior to EDTA, no protection if delayed until 15 min prior to EDTA.

LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static, pH 8.9; Concentration: 486 mg/L for 96 hr /Versene powder/

LC50; Species: Lepomis macrochirus (Bluegill) 0.74 (0.62-1.28) g, 34 (28-38) mm; Conditions: static; Concentration: 1,030 mg/L for 96 hr (95% confidence interval: 980-1,080 mg/L) /39.00 % a.i., Versene 100/

LC50; Species: Lepomis macrochirus (Bluegill) weight 0.74 (0.62-1.28) g, length 34 (28-38) mm; Conditions: static; Concentration: 3,092 mg/L for 96 hr (95% confidence interval: 2,320-3,540 mg/L) /41.10 % a.i., Versene FE-3/

LC50; Species: Daphnia magna (Water Flea) age < or = 24 hr; Conditions: freshwater, static, 20-22 °C, pH 7.6-7.7; Concentration: 625000 ug/L for 24 hr /formulation/

Cough. Sore throat.

Redness.

Redness. Pain.

Burning sensation in the throat and chest. Abdominal pain. Diarrhoea.

/HUMAN EXPOSURE STUDIES/ Tetrasodium edetate used in dust as sequestering agent should not be applied to eye unless first neutralized, because it forms solution sufficiently alkaline to be injurious to eye.

/SIGNS AND SYMPTOMS/ Rapid intravenous administration of Na2EDTA causes hypocalcemic tetany. However, a slow infusion (15 mg per minute) administered to a normal individual elicits no symptoms of hypocalcemia because of the ready availability of extracirculatory stores of calcium.

/CASE REPORTS/ A 75-year-old man being treated for several malignant epithelial tumors was prescribed a sunscreen Uriage SPF50+ cream. After 10 months of using the product, the patient presented with eczematous areas where the sunscreen had been applied (face, neck and back of hands). Patch testing was performed with standard series of GEIDAC (Spanish Contact Dermatitis and Cutaneous Allergy Research Group), sunscreen series (Chemotechnique Diagnostics, Malmo, Sweden) and the Uriage SPF50+ cream. After 4 days, a positive reaction was observed to the cream (++). The manufacturer supplied the individual ingredients of their product. Out of the 24 components provided, only tetrasodium ethylenediaminetetraacetic acid (EDTA) 0.2% aqua was positive and it was negative in five controls subjects. ... In our patient, there was a close relation between the application of the sunscreen and the appearance of eczema. Positive patch test was only obtained with 0.2% aqua tetrasodium EDTA as a component of the sunscreen, whereas ethylenediamine was negative. His eczema resolved once the sunscreen ceased to be used. He is now using a mineral-based product without EDTA.

/OTHER TOXICITY INFORMATION/ .../Edetic acid/ and many of its salts bind metal cations tightly and so render them essentially innocuous. /EDTA and its salts/

For more Human Toxicity Excerpts (Complete) data for TETRASODIUM EDTA (6 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ Based on limited experimental data and lack of reports of skin and respiratory sensitisation during industrial use of edetic acid and Na4EDTA, the /investigators/ conclude that both edetic acid and Na4EDTA do not cause sensitisation by skin contact or by inhalation. Based on the positive results with the Magnusson-Klingman test, the CSTEE concludes that edetic acid salts may be weak skin sensitizers.

/LABORATORY ANIMALS: Acute Exposure/ Not irritating to skin of rabbits. Irritating to rabbit eyes.

/LABORATORY ANIMALS: Acute Exposure/ Trilon b at 200-400 mg/kg caused tetanic convulsions and death of rabbits and mice.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ When administered in drinking water to white mice, EDTA ... and, Tetrasodium EDTA ... produced changes in the mineral content of the tissues. EDTA was administered at a concentration of 3.4 mM (due to its low solubility in water) and the salts were administered at concentrations of 25 mM. The mineral content of bones, kidneys, liver, and muscles was determined using atomic absorption spectrophotometry. ... After treatment with Tetrasodium EDTA, calcium was reduced in bone, liver, and muscle; zinc was reduced in the kidneys, muscle, and liver; and magnesium was reduced in bone and liver. ... Mice given EDTA had increased muscle calcium; and mice treated with Tetrasodium EDTA had increased renal magnesium. Similar results were /previously/ reported after oral administration of 1 mmol/kg/day EDTA for 35 days in a study using 42 male Wistar rats.

For more Non-Human Toxicity Excerpts (Complete) data for TETRASODIUM EDTA (11 total), please visit the HSDB record page.

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of tetrasodium EDTA is 1000 or greater; the data may be greatly underestimated(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,388,281 workers (611,582 of these were female) were potentially exposed to tetrasodium EDTA in the US(1).

Give ... calcium gluconate ... or ... calcium chloride slowly iv. Repeat as needed every 5 to 10 minutes.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

LD50 Mouse ip 330 mg/kg

LD50 Rat ip >2.0 g/kg

LD50 Rat ip 4000 mg/kg bw

Chemical: Glycine, N,N′-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4)

Chemical: Glycine, N,N′-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:?)

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14817

Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15231；Status: Active Update: 21-01-2015 https://echa.europa.eu/registration-dossier/-/registered-dossier/6906

Tetrasodium EDTA: Does not have an individual approval but may be used under an appropriate group standard

Residues of ethylenediaminetetraacetic acid, tetrasodium salt are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: sequestrant. Limit: 5% of pesticide formulation.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), tetrasodium salt is included on this list.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), tetrasodium salt is included on this list.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Tetrasodium ethylenediaminetetraacetate is found on List D. Case No: 4036; Pesticide type: insecticide, fungicide, herbicide, antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): tetrasodium ethylenediaminetetraacetate; AI Status: Registrants of the pesticide have not made or honored a commitment to seek reregistration, conduct the necessary studies, or pay the requisite fees, or they have asked EPA to cancel their product registrations. Unless some other interested party supports them, products containing the pesticide will be cancelled.

S - Sensory organs；S01 - Ophthalmologicals；S01X - Other ophthalmologicals；S01XA - Other ophthalmologicals；S01XA05 - Sodium edetate

QS - Sensory organs；QS01 - Ophthalmologicals；QS01X - Other ophthalmologicals；QS01XA - Other ophthalmologicals；QS01XA05 - Sodium edetate

CIR ingredient: Tetrasodium EDTA

Used as a chelating agent; [Hawley] Used in agricultural, chemical, electrical/electronic engineering, leather processing, metal extraction, refining, and processing, paint, lacquers, and varnishes, paper-pulp-board, photographic, polymers, textiles, oil field, metal finishing, water treatment, food, pharmaceutical, and personal, industrial, and domestic cleaners industries; [IUCLID]

Petroleum Production and Refining [Category: Industry]；Pulp and Paper Processing [Category: Industry]；Textiles (Fiber & Fabric Manufacturing) [Category: Industry]；Painting (Pigments, Binders, and Biocides) [Category: Paint]；Sewer and Wastewater Treatment [Category: Industry]；Leather Tanning and Processing [Category: Industry]；Photographic Processing [Category: Other]；Metal Extraction and Refining [Category: Industry]

For EDTA tetrasodium salt (USEPA/OPP Pesticide Code: 039107) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

General-purpose chelating agent.

Tetrasodium EDTA can be used in sanitizing solutions for use on food processing equipment and utensils and on food-contact surfaces in public eating places.

2023: 100,000,000 - <250,000,000 lb；2022: 100,000,000 - <250,000,000 lb；2021: 100,000,000 - <250,000,000 lb；2020: 100,000,000 - <250,000,000 lb

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).[EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program. Glycine, N,N'-1,2-ethanediylbis

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4991]；[US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Glycine, N,N'-1,2-ethanediylbis

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt. Aggregated National Production Volume: 100 to < 500 million pounds.[US EPA; Non-Confidential 2006 Inventory Update Reporting. National Chemical Information. Glycine, N,N'-1,2-ethanediylbis

Surface modifier；Chelating agent；Etching agent；Stabilizing agent；Ion exchange agent；Not Known or Reasonably Ascertainable；Soil amendments (fertilizers)；Cleaning agent；Plating agent；Processing aids not otherwise specified；Surfactant (surface active agent)；Other；CBI；Anti-adhesive/cohesive

Tetrasodium EDTA was formed by reacting a basic solution of ethylenediamine with formaldehyde and sodium or hydrogen cyanide, followed by hydrolysis to form the salt. It can also be produced by using excess sodium hydroxide in the reaction. The intermediate ethylenediaminetetracetonitrile can be isolated and hydrolyzed ... in a separate step. It was supplied either in anhydrous form or hydrated with two molecules of water per molecule of the salt.

The cosmetic-grade material contains a minimum of 99.0% Tetrasodium EDTA as Na4EDTA.2H2O

Anhydrous or dihydrate.

Fragrance Ingredients

Cosmetics -> Chelating

Computer and Electronic Product Manufacturing；Wholesale and Retail Trade；Agriculture, Forestry, Fishing and Hunting；Synthetic Rubber Manufacturing；Oil and Gas Drilling, Extraction, and Support activities；Soap, Cleaning Compound, and Toilet Preparation Manufacturing；CBI；Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing；All Other Basic Inorganic Chemical Manufacturing；Utilities；Rubber Product Manufacturing；All Other Basic Organic Chemical Manufacturing；Other (requires additional information)；Asphalt Paving, Roofing, and Coating Materials Manufacturing；Food, beverage, and tobacco product manufacturing；Paper Manufacturing；Miscellaneous Manufacturing；Construction；All Other Chemical Product and Preparation Manufacturing；Not Known or Reasonably Ascertainable

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4): ACTIVE

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:?): ACTIVE

A number of salts of EDTA are available with uses identical or similar to the acid. The USP salts are called edetates (calcium disodium, disodium edetates); others are usually abbreviated to EDTA (tetrasodium, trisodium EDTA). Other salts, known chiefly under trademark names, are the sodium ferric, dihydrogen ferrous and a range of disodium salts with magnesium, divalent cobalt, manganese, copper, zinc, and nickel.

Historical data (data submitted to the FDA in 1984) indicated that EDTA and Tetrasodium EDTA were used typically at concentrations up to 1%, but one formulation each contained concentrations of 25%.

It has been estimated that daily human consumption of EDTA salts are 1.5 x 10-4 for Tetrasodium EDTA.