Edetate Sodium → N-Palmitoylglycine

HRID 521811

반응식

HRID 521811 반응식
[NH:1]([C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:17])[CH2:2][C:3](N[C@H](C(O)=O)CC1N=CNC=1)=[O:4].C(N(CC([O-])=O)CC([O-])=O)CN(CC([O-])=O)CC([O-])=[O:38].[Na+].[Na+].[Na+].[Na+]>>[NH:1]([C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:17])[CH2:2][C:3]([OH:4])=[O:38]

참가 물질

3

반응물 2

HCID 6144Edetate Sodium2회HCID 178443076HCID 178443076, 화합물2회

생성물 1

HCID 151008N-Palmitoylglycine

실험 절차

N-palmitoyl-Gly-His obtained in the above-described synthesis example was added in a screw bottle (manufactured by Maruemu Corporation) such that the concentration of N-palmitoyl-Gly-His was 1.0 wt % (w/w) and the concentration of an additive (sodium ethylenediaminediacetate, sodium ethylenediaminetetraacetate) was 1.0 wt % (w/w), and a stirring bar (manufactured by As One Corporation, 4 mm×10 mm) was put thereinto. The additives (each having a pH that is outside the range of 6.5 to 9.3 or 1.8 to 2.5) are outside the scope of the present invention. Next, heating and stirring were performed, with a cap of the screw bottle being open, in a water bath (NWB-180N, manufactured by Nissinrika K. K.) for 60 minutes at a maximum until a transparent dispersion state was confirmed at 80° C. After heating and stirring, there were no undissolved residues in the solution with sodium ethylenediaminetetraacetate, whereas undissolved residues were observed by visual inspection in the other.

후처리

  1. temperatureNext, heating
  2. customwith a cap of the screw bottle
  3. custombeing open, in a water bath
  4. temperatureAfter heating
  5. stirringstirring

출처 및 근거

ORD 기록
ord-9a71e7efdad948368c8e68564335ae2d
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328137B2

연결된 노트

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