AcridineOrangeForMicroscopical염색
Acridine Orange Base
기본 정보
- CAS
17251-70-6- 표준 SMILES
CN(C)c1ccc2cc3ccc(N(C)C)cc3nc2c1- InChIKey
DPKHZNPWBDQZCN-UHFFFAOYSA-N- 분자식
- C17H19N3
- 평균 분자량
- 265.35 g/mol
- 단동위원소 질량
- 265.15789761
개요
Acridine orange free base is a member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. It has a role as a fluorochrome and a histological dye. It is an aromatic amine, a tertiary amino compound and a member of aminoacridines.
이름 및 식별자
- 우선 이름
- Acridine Orange Base
- IUPAC
- 3-N,3-N,6-N,6-N-tetramethylacridine-3,6-diamine
- 현지명
- AcridineOrangeForMicroscopical염색
- 영어명
- AcridineOrangeForMicroscopicalStaining
- 분자식
- C17H20N3+
- 분자량
- 266.3608
이름 및 동의어
Acridine orange494-38-2Acridine Orange Base3,6-Bis(dimethylamino)acridineWaxoline Orange AOranz akridinova3,6-Di(dimethylamino)acridineRhoduline OrangeC.I. No. 46005:1Oranz rozpoustedlova 15Basic Orange 14Acridine Orange NO
이름 더 보기
AcridineOrangeForMicroscopical염색AcridineOrangeForMicroscopicalStaining3,6-Acridinediamine, N,N,N,N-tetramethyl-, conjugate monoacid
Rhoduline Orange NOF30N4O6XVVDTXSID60197783NSC-194350Acridine Orange NAcridine Orange RAcridine Orange NSSumitomo Acridine Orange NO
데이터베이스 식별자
- CAS
17251-70-6、494-38-2- PubChem CID
- 62344
- DTXSID
DTXSID60197783- ChEMBL
CHEMBL81880- ChEBI
CHEBI:87346
물성
구조 계산 물성
- XLogP
- 3.4
- 극성 표면적
- 19.4 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 20
- 형식 전하
- 0
- 복잡도
- 298
실험 및 물리화학적 성질
Chemical Classes
Dyes -> Acridine Dyes
Dyes -> Acridine Dyes
Physical DescriptionSolid; [Sigma-Aldrich MSDS]
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory Information
Chemical: 3,6-Acridinediamine, N,N,N',N'-tetramethyl-
Acridine orange: Does not have an individual approval but may be used under an appropriate group standard
Acridine orange base: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Has mutagenic potential that is enhanced by light; Acridine dyes are derived from 3,6-diaminoacridine, 9-(4'-aminophenyl)-3-aminoacridine, and 9-(4'-aminophenyl)-3,6-diaminoacridine. One of the oldest acridine dyes is chrysaniline. Acridine dyes have low light fastness. In the past they were used for printing on cotton. Currently, they are not commercially important. [Ullmann] See Acridine.
May cause irritation; Targets the blood; Mutagenic effects observed in laboratory experiments; [Sigma-Aldrich MSDS] See Acridine orange.
안전 및 보호
Protective Action Criteria (PAC)
0.090 [mg/m3]
0.98 [mg/m3]
5.9 [mg/m3]
독성 정보
Carcinogen Classification
Acridine orange
Group 3: Not classifiable as to its carcinogenicity to humans
Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals
1987
1987
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
용도 및 제조
Uses
N,N,N',N'-Tetramethyl-3,6-acridinediamine, monohydrochloride. Cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms. [ChemIDplus]
A coloring agent; [IARC]
관련 반응
6건
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