AcridineOrangeForMicroscopical염색

Acridine Orange Base

HCID 62344CAS 17251-70-6

기본 정보

표준 SMILES: CN(C)c1ccc2cc3ccc(N(C)C)cc3nc2c1
InChIKey: DPKHZNPWBDQZCN-UHFFFAOYSA-N
분자식: C17H19N3
평균 분자량: 265.35 g/mol
단동위원소 질량: 265.15789761

개요

Acridine orange free base is a member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. It has a role as a fluorochrome and a histological dye. It is an aromatic amine, a tertiary amino compound and a member of aminoacridines.

이름 및 식별자

우선 이름: Acridine Orange Base
IUPAC: 3-N,3-N,6-N,6-N-tetramethylacridine-3,6-diamine
현지명: AcridineOrangeForMicroscopical염색
영어명: AcridineOrangeForMicroscopicalStaining
분자식: C17H20N3+
분자량: 266.3608

이름 및 동의어

Acridine orange494-38-2Acridine Orange Base3,6-Bis(dimethylamino)acridineWaxoline Orange AOranz akridinova3,6-Di(dimethylamino)acridineRhoduline OrangeC.I. No. 46005:1Oranz rozpoustedlova 15Basic Orange 14Acridine Orange NO

이름 더 보기

AcridineOrangeForMicroscopical염색AcridineOrangeForMicroscopicalStaining3,6-Acridinediamine, N,N,N,N-tetramethyl-, conjugate monoacid

Rhoduline Orange NOF30N4O6XVVDTXSID60197783NSC-194350Acridine Orange NAcridine Orange RAcridine Orange NSSumitomo Acridine Orange NO

데이터베이스 식별자

CAS: 17251-70-6、494-38-2
PubChem CID: 62344
DTXSID: DTXSID60197783
ChEMBL: CHEMBL81880
ChEBI: CHEBI:87346
UNII: F30N4O6XVV
EC Number: 610-452-6
Nikkaji: J1.559H

물성

구조 계산 물성

XLogP: 3.4
극성 표면적: 19.4 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 3
회전 가능 결합 수: 2
무거운 원자 수: 20
형식 전하: 0
복잡도: 298

실험 및 물리화학적 성질

Chemical Classes · 2건

Dyes -> Acridine Dyes

Physical DescriptionSolid; [Sigma-Aldrich MSDS]

안전 및 규제

유해성 정보

Regulatory Information · 3건

Chemical: 3,6-Acridinediamine, N,N,N',N'-tetramethyl-

Acridine orange: Does not have an individual approval but may be used under an appropriate group standard

Acridine orange base: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 2건

Has mutagenic potential that is enhanced by light; Acridine dyes are derived from 3,6-diaminoacridine, 9-(4'-aminophenyl)-3-aminoacridine, and 9-(4'-aminophenyl)-3,6-diaminoacridine. One of the oldest acridine dyes is chrysaniline. Acridine dyes have low light fastness. In the past they were used for printing on cotton. Currently, they are not commercially important. [Ullmann] See Acridine.

May cause irritation; Targets the blood; Mutagenic effects observed in laboratory experiments; [Sigma-Aldrich MSDS] See Acridine orange.

안전 및 보호

Protective Action Criteria (PAC) · 3건

0.090 [mg/m3]

0.98 [mg/m3]

5.9 [mg/m3]

독성 정보

Carcinogen Classification · 5건

Acridine orange

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals

1987

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.

용도 및 제조

Uses · 2건

N,N,N',N'-Tetramethyl-3,6-acridinediamine, monohydrochloride. Cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms. [ChemIDplus]

A coloring agent; [IARC]