Acridine Orange Base → 10-N(10-Hydroxy-1-decyl)-3,6 bis(dimethylamino)acridine bromide salt

HRID 983784

반응식

HRID 983784 반응식
[CH3:1][N:2]([CH3:20])[C:3]1[CH:4]=[CH:5][C:6]2[C:15]([CH:16]=1)=[N:14][C:13]1[C:8](=[CH:9][CH:10]=[C:11]([N:17]([CH3:19])[CH3:18])[CH:12]=1)[CH:7]=2.[OH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][Br:32]>CN(C=O)C>[Br-:32].[OH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:14]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N:17]([CH3:19])[CH3:18])[CH:12]=2)[CH2:7][C:6]2[CH:5]=[CH:4][C:3]([N:2]([CH3:20])[CH3:1])=[CH:16][C:15]1=2

참가 물질

4

반응물 2

HCID 62344Acridine Orange Base2회HCID 1045071-Decanol, 10-bromo-

생성물 1

HCID 8675334110-N(10-Hydroxy-1-decyl)-3,6 bis(dimethylamino)acridine bromide salt

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3,6-bis(dimethylamino)acridine (1.0 millimole) is dissolved in DMF (100 mL) containing 1.1 equivalent of tertiary amine base. To this is added 10-hydroxy-1-bromo decane (1.1 millimole), and the mixture is heated to reflux. When monitoring by TLC shows no remaining 3,6-bis(dimethylamino)acridine, the reaction is cooled and the 10-N-(10-hydroxy-1-decyl)-3,6-bis(dimethylamino)acridine is isolated (0.75 millimoles).

후처리

  1. temperaturethe mixture is heated to reflux
  2. temperaturethe reaction is cooled

출처 및 근거

ORD 기록
ord-1e2b3d3d9e1a49aeafadb26dd622ce8a
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867197B1

연결된 노트

불러오는 중…