하이드록시프로제스테론

17-Hydroxyprogesterone

기본 정보

CAS: 110850-01-6
표준 SMILES: CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
InChIKey: DBPWSSGDRRHUNT-CEGNMAFCSA-N
분자식: C21H30O3
평균 분자량: 330.5 g/mol

개요

17alpha-hydroxyprogesterone is a 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone. It has a role as a metabolite, a progestin, a mouse metabolite and a human metabolite. It is a 17alpha-hydroxy-C21-steroid, a tertiary alpha-hydroxy ketone and a 17alpha-hydroxy steroid. It is functionally related to a progesterone.

이름 및 식별자

우선 이름: 17-Hydroxyprogesterone
IUPAC: (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
현지명: 하이드록시프로제스테론
영어명: 17α-Hydroxyprogesterone
분자식: C21H30O3
분자량: 330.46

이름 및 동의어

hydroxyprogesterone68-96-217ALPHA-HYDROXYPROGESTERONE17-HydroxyprogesteroneProdixProdoxGestageno gador17-alpha-Hydroxyprogesterone17-Hydroxypregn-4-ene-3,20-dioneGestagenoHidroxiprogesteronaHydroxyprogesteronum

이름 더 보기

하이드록시프로제스테론17A-HYDROXYPROGESTERONE17α-Hydroxyprogesterone17-OHPHYDROXYPROGESTERONE, 17A-U 3096

17alpha-Hydroxy-4-pregnene-3,20-dione17-OH Progesteronedelta(4)-Pregnene-17alpha-ol-3,20-dione17alpha-Hydroxy-progesteronePregn-4-ene-3,20-dione-17-olIdrossiprogesteronealpha Hydroxy progesteroneDTXSID6040747

데이터베이스 식별자

CAS: 110850-01-6、68-96-2
PubChem CID: 6238
DTXSID: DTXSID00859075
ChEMBL: CHEMBL1062

물성

구조 계산 물성

XLogP: 3.2
극성 표면적: 54.4 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 3
회전 가능 결합 수: 1
무거운 원자 수: 24
형식 전하: 0
복잡도: 635

실험 및 물리화학적 성질

LipidsLipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]

SpringerMaterials PropertiesChemical shift

LogP3.17

Color/FormRHOMBIC OR HEXAGONAL LEAFLETS FROM ACETONE OR ALCOHOL

Solubility0.00648 mg/mL

Animal DrugsPharmaceuticals -> Animal Drugs -> Approved in Taiwan

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Danger

H360 (95.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory.

유해성 정보

Regulatory Information · 2건

Status: Active Update: 28-07-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/20280

Hydroxyprogesterone: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Pregn-4-ene-3,20-dione, 17-hydroxy-: Environment tier I assessment

Hazard Classes and CategoriesRepr. 1B (95.1%)

독성 정보

Interactions...ESTROGEN ENHANCED SUPPRESSIVE EFFECT OF PROGESTIN & LED TO GENERAL USE OF MIXTURE OF TWO. /PROGESTINS/

Human Toxicity Excerpts · 5건

...MAY CAUSE EDEMA & LOCAL REACTIONS @ SITE OF INJECTION.

MOST COMMON EFFECTS ARE NAUSEA, EDEMA, & IRREGULAR VAGINAL BLEEDING. OTHER REPORTED EFFECTS INCL WT GAIN, DECR LIBIDO, DEPRESSION, JAUNDICE, & CONGESTIVE HEART FAILURE. /CAPROATE/

...HYDROXYPROGESTERONE CAPROATE OCCASIONALLY CAUSES HYPERSENSITIVITY, COUGHING, OR DYSPNEA. IN RARE INSTANCES IT MAY CAUSE VIRILIZATION OF FEMALE FETUS. /CAPROATE/

CONTINUOUS ADMIN OF PROGESTIN IN SUFFICIENT DOSE ABOLISHES CYCLE FOR AS LONG AS IT IS GIVEN & LEADS TO OVARIAN & ENDOMETRIAL ATROPHY. VERY SMALL DOSES MAY ALTER STRUCTURE OF ENDOMETRIUM & CONSISTENCY OF CERVICAL MUCUS WITHOUT DISRUPTING CYCLE OR INHIBITING OVULATION. /PROGESTINS/

화학 및 산업

약리 정보

ATC Code · 2건

G - Genito urinary system and sex hormones

QG - Genito urinary system and sex hormones

Mechanism of Action · 2건

ADMIN OF ESTROGEN & PROGESTIN, AS CONTAINED IN COMBINATION OR SEQUENTIAL PREPN, COULD INTERFERE WITH FERTILITY IN ANY ONE OF SEVERAL WAYS. HOWEVER, IT IS CLEAR THAT, AS CURRENTLY USED, MIXTURE INHIBITS OVULATION. ...CONTINUED ACTION OF PROGESTERONE SERVES TO INHIBIT RELEASE OF LH. /PROGESTINS/

IT ACTS AS ANTIGONADOTROPHIC AGENT ON ANTERIOR PITUITARY INHIBITING FSH RELEASE &, THUS, FOLLICULAR GROWTH, ESTROGEN PRODUCTION, & ESTRUS. IT ALSO INHIBITS LH RELEASE, THUS PREVENTING OVULATION, CORPORA LUTEA FORMATION, & FURTHER PROGESTERONE SECRETION. BY INHIBITING LH...HOLDS PROGESTERONE LEVELS IN CHECK.

Metabolism/Metabolites17alpha-hydroxy-progesterone has known human metabolites that include 17Beta-21-dihydroxyprogesterone.

FDA Pharmacological Classification · 5건

21807M87J2

HYDROXYPROGESTERONE

Chemical Structure [CS] - Progesterone Congeners

Established Pharmacologic Class [EPC] - Progestin

Hydroxyprogesterone is a Progestin.

Absorption, Distribution and Excretion · 3건

...DURATION OF ACTION IS LONGER /THAN PROGESTERONE/, BUT ITS ONSET OF ACTION IS SLOWER. SINGLE INJECTION OF SOLN OF HYDROXYPROGESTERONE CAPROATE IN OIL WILL EXERT PROGESTATIONAL EFFECTS FOR 1-2 WK. /CAPROATE/

ABOUT 50-60% OF ADMIN RADIOACTIVE PROGESTERONE APPEARS IN URINE & ABOUT 10% IN FECES. ... WHEN PROGESTERONE IS GIVEN FOR PROLONGED PERIOD, DURING LUTEAL PHASE OF CYCLE, OR DURING PREGNANCY, LARGER PROPORTION (25-30%) APPEARS IN URINE AS PREGUANEDIOL. /PROGESTERONE/

RATE OF TURNOVER OF ENDOGENOUS PROGESTERONE IS UNUSUALLY RAPID, T/2 IN BLOOD BEING FEW MIN, & DOUBTLESS EXOGENOUS MATERIAL IS HANDLED IN SAME WAY. SMALL AMT...IS STORED IN BODY FAT... PRESUMABLY, ABSORPTION FROM INTESTINAL TRACT IS PROMPT, BUT COMPD IS RAPIDLY TRANSFORMED DURING PASSAGE THROUGH LIVER... /PROGESTERONE/

Tissue LocationsAdipose Tissue

화합물 노트

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기본 정보

CAS: 110850-01-6
표준 SMILES: CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
InChIKey: DBPWSSGDRRHUNT-CEGNMAFCSA-N
분자식: C21H30O3
평균 분자량: 330.5 g/mol

개요