암로디핀말레에이트

Amlodipine Maleate

HCID 6435922
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기본 정보

CAS
88150-47-4
표준 SMILES
CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.O=C(O)/C=C\C(=O)O
InChIKey
TZNOWAJJWCGILX-BTJKTKAUSA-N
분자식
C24H29ClN2O9
평균 분자량
524.9 g/mol
단동위원소 질량
524.15615819

개요

Amlodipine Maleate is the maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.

이름 및 식별자

우선 이름
Amlodipine Maleate
IUPAC
(Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
현지명
암로디핀말레에이트
영어명
Amlodipine maleate
분자식
C30H35ClN2O12S
분자량
524.95

이름 및 동의어

Amlodipine maleate88150-47-4AmvazCQ27G2BZJMUK-48,340-11UK-48340-11DTXSID601027708RefChem:54171DTXCID901513285Amlodipine (maleate)Amlodipine maleate [USAN]3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate
이름 더 보기
암로디핀말레에이트Amlodipine IH Impurity AAmlodipine maleate USP/EP/BPAmlodipine maleate - Bio-X ?AMLODIPINE MALEATE MM STANDARDAmlodipine maleate (crystalline)Amlodipine maleate, 10 mM in DMSOAmlodipineMaleateC20H25C1N205.C4H4043-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5
UNII-CQ27G2BZJMMFCD02259457(Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate1357024-06-6Amlodipine maleate (USAN)C24H29ClN2O9Amlodipine (+-)-form maleateUK 48,340-11

데이터베이스 식별자

CAS
88150-47-4
PubChem CID
6435922
DTXSID
DTXSID601027708
ChEMBL
CHEMBL1200984
UNII
CQ27G2BZJM
EC Number
629-849-0

물성

구조 계산 물성

극성 표면적
174 Ų
수소 결합 공여자 수
4
수소 결합 수용자 수
11
회전 가능 결합 수
12
무거운 원자 수
36

실험 및 물리화학적 성질

Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점
178 · 178-179°
저장 조건
Sealed in dry,Room Temperature
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
색상
황백색에서 연한 노란색
안정성
감광성

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H301 (40%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 3 (40%)

안전 데이터

신호 어
Warning
유해·위험 문구
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 3건

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

Drugs used to cause dilation of the blood vessels.

응용 분야

용도Anti-anginal; antihypertensive.

상·하류 제품 정보

공급사100 곳

北京华美互利生物化工010-56205725 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

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