Ethanol → Amlodipine Maleate

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[N:1]([CH2:4][CH2:5][O:6][CH2:7][C:8]1[NH:9][C:10]([CH3:30])=[C:11]([C:26]([O:28][CH3:29])=[O:27])[CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N+]=[N-].[H][H].C([OH:35])C>[Pd]>[C:7]([OH:6])(=[O:35])/[CH:8]=[CH:13]\[C:14]([OH:16])=[O:15].[NH2:1][CH2:4][CH2:5][O:6][CH2:7][C:8]1[NH:9][C:10]([CH3:30])=[C:11]([C:26]([O:28][CH3:29])=[O:27])[CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

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실험 절차

A suspension of 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (103 g) in ethanol (2.5 l) was stirred for 16 hours at room temperature under one atmosphere of hydrogen in the presence of 5% palladium on calcium carbonate (40 g). The reaction mixture was filtered and evaporated and the residue treated with a solution of maleic acid (22 g) in ethanol (100 ml). The reaction mixture was stirred at room temperature for 2 hours and then the resulting solid collected, washed with ethanol, and dried to give the title compound (100 g), m.p. 169°-170.5°.