Benzydamine Hydrochloride

HCID 65464CAS 132-69-4
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12.Cl
InChIKey
HNNIWKQLJSNAEQ-UHFFFAOYSA-N
분자식
C19H24ClN3O
평균 분자량
345.9 g/mol
단동위원소 질량
345.16079007

개요

Benzydamine hydrochloride is a member of indazoles.

이름 및 식별자

우선 이름
Benzydamine Hydrochloride
IUPAC
3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine;hydrochloride
영어명
Benzydamine hydrochloride
분자식
C19H23N3O.ClH
분자량
345.87

이름 및 동의어

Benzydamine hydrochloride132-69-4Benzydamine HClBenzidamine hydrochlorideTantumBenalginDorinaminBenzyrinEpirotinSalyzoronDifflamEnzamin
이름 더 보기
af864Afloben
ImotrylIndolinRirilimRiripenTamasVeraxAF 864DTXSID1045293

데이터베이스 식별자

CAS
132-69-4
PubChem CID
65464
DTXSID
DTXSID1045293
ChEMBL
CHEMBL1528134
ChEBI
CHEBI:31266
UNII
K2GI407R4Q
EC Number
205-076-0

물성

구조 계산 물성

극성 표면적
30.3 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
3
회전 가능 결합 수
7
무거운 원자 수
24

실험 및 물리화학적 성질

Chemical ClassesOther Uses -> Pharmaceuticals
Solubility22.5 [ug/mL] (The mean of the results at pH 7.4)
Collision Cross Section170.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

물리화학적 성질

녹는점
147 · 147-153°C
저장 조건
2 · Inert atmosphere,2-8°C
용해도
클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
Solid
색상
흰색에서 황백색까지
수용성
Soluble in water, ethanol, chloroform, n-butanol or DMSO /n

화학적 성질

Off-White Solid

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 105 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Other Safety InformationIMAP assessments - 1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-, monohydrochloride: Environment tier I assessment
Hazards SummaryAllergic and photoallergic contact dermatitis reported; [Kanerva, p. 1757]
Hazard Classes and CategoriesAcute Tox. 4 (100%)

독성 정보

Adverse EffectsDermatotoxin - PACD (photoallergic contact dermatitis).

안전 데이터

wgk
3
rtecs
NK7875000
독성
LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini)
HS 번호
2933.99.8290
risk_code
20/21/22-36
hazard_code
Xn

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationSubstances that reduce or suppress INFLAMMATION.

용도 및 제조

UsesUsed as a topical, non-steroidal anti-inflammatory drug (NSAID); [Kanerva, p. 1757]
응용 분야 · 2건

개요Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.

용도Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.

상·하류 제품 정보

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

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