Benzydamine Hydrochloride
BENZYDAMINE HCL · af864 · tamas · verax · tantum · riripen · ririlim · indolin
식별자 및 물리적 특성
| CAS No. | 132-69-4 |
|---|---|
| 분자식 | C19H24ClN3O |
| 평균 분자량 | 345.9 g/mol |
| 단동위원소 질량 | 345.16079007 g/mol |
| SMILES | CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12.Cl |
| InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
| PubChem CID | 65464 |
| ChEMBL | CHEMBL1528134 |
| ChEBI | CHEBI:31266 |
| EC No. | 205-076-0 |
| DTXSID | DTXSID1045293 |
화학 및 물리적 성질
| 극성 표면적 | 30.3 |
|---|---|
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 7 |
| 무거운 원자 수 | 24 |
| 형식 전하 | 0 |
| 복잡도 | 344 |
| 물질 분류 | Other Uses -> Pharmaceuticals |
| 용해도 | 22.5 [ug/mL] (The mean of the results at pH 7.4)클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨) |
| Collision Cross Section | 170.9 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| 녹는점 | 147-153°C |
| 저장 조건 | Inert atmosphere,2-8°C |
| 물리적 상태 | Solid |
| 색상 | 흰색에서 황백색까지 |
| 용해도 | Soluble in water, ethanol, chloroform, n-butanol or DMSO /n |
| Merck | 14,1122 |
| 주요 응용 | 법의학 및 독성학의약품(소분자)수의사 |
| InChI | InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H31H |
| InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC=1C(=NN2CC1C=CC=CC=1)OCCCN(C)C.Cl |
화학적 성질
Off-White Solid
안전 및 규제
| GHS 분류 | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 105 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 기타 안전 정보 | IMAP assessments - 1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-, monohydrochloride: Environment tier I assessment |
| 유해성 요약 | Allergic and photoallergic contact dermatitis reported[Kanerva, p. 1757] |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| 유해 작용 | Dermatotoxin - PACD (photoallergic contact dermatitis). |
| 수질 위해 등급(WGK) | 3 |
| RTECS 번호 | NK7875000 |
| 독성 | LD50 in mice, rats (mg/kg): 110, 100 i.p.515, 1050 orally (Silvestrini) |
| 관세 코드 | 2933.99.8290 |
| 위험 문구(R) | 20/21/22-36 |
| 위험 표시 | Xn |
| 안전 문구(S) | 26-36 |
| 위험 등급 | Acute Tox. 4 OralEye Irrit. 2 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
용도
Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.