Betamethasone Sodium Phosphate

HCID 65478CAS 151-73-5

기본 정보

표준 SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]
InChIKey
PLCQGRYPOISRTQ-LWCNAHDDSA-L
분자식
C22H28FNa2O8P
평균 분자량
516.4 g/mol
단동위원소 질량
516.13012157

이름 및 식별자

우선 이름
Betamethasone Sodium Phosphate
IUPAC
disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
영어명
Betamethasone 21-phosphate disodium
분자식
C22H28FNa2O8P
분자량
516.4

이름 및 동의어

151-73-5Betamethasone sodium phosphateBetamethasone disodium phosphateBetamethasone 21-disodium phosphateBetamethasone 21-phosphate disodiumBetamethasone 21-phosphate disodium saltBetamethazone disodium phosphateDTXSID80471377BK02SCL3W9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate)NSC-90616CHEBI:3078
이름 더 보기
DurabetasonbetnesolbentelanCelestanBentalanNSC 90616Vista-Methasone
DTXCID6027137Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-betamethason sodium phosphateVistamethasoneBetam-ophtalVistamethasone nNSC90616RefChem:54528

데이터베이스 식별자

CAS
151-73-5
PubChem CID
65478
DTXSID
DTXSID8047137
ChEMBL
CHEMBL1200762
ChEBI
CHEBI:3078
UNII
7BK02SCL3W
EC Number
205-797-0
Nikkaji
J7.409H

물성

구조 계산 물성

극성 표면적
147 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
9
회전 가능 결합 수
3
무거운 원자 수
34

물리화학적 성질

녹는점
206 · 206-211°C
저장 조건
room temp
용해도
물에 잘 녹고, 에탄올(96%)에 약간 녹으며, 염화메틸렌에는 거의 녹지 않습니다.
물리적 상태
Solid
색상
흰색에서 황백색까지
수소이온지수(pH)
7.5 · 7.5~9.0(5g/l, 25℃)

화학적 성질

White or almost white powder, very hygroscopic.

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H302 (44.2%): Harmful if swallowed [Warning Acute toxicity, oral];H330 (54.9%): Fatal if inhaled [Danger Acute toxicity, inhalation];H360 (42.5%): May damage fertility or the unborn child [Danger Reproductive toxicity];H360D (15%): May damage the unborn child [Danger Reproductive toxicity];H372 (48.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure];H373 (12.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure];H410 (46.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P271, P273, P280, P284, P301+P317, P304+P340, P316, P318, P319, P320, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 113 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information · 1건

IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Environment tier I assessment;IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Human health tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (44.2%);Acute Tox. 2 (54.9%);Repr. 1B (42.5%);Repr. 1B (15%);STOT RE 1 (48.7%);STOT RE 2 (12.4%);Aquatic Chronic 1 (46.9%)

규제 정보

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk
3
rtecs
TU4056500
독성
LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90
HS 번호
29372290
risk_code
22
hazard_code
Xn

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 1건

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

용도 및 제조

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

추가 설명

정의ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

관련 반응

2건

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