Propacetamol

Propacetamo · Pro-Dafalgan · PROPACETAMOL · Propacatemol · Propacetamol USP/EP/BP · 4-Acetamidophenyl N,N-diethylglycinate · 4-acetamidophenyl N,N-diethylaminoacetate · N，N-Diethylglycine 4-(acetylamino)phenyl ester

https://huagongshe.com/ko/chemical/68865

식별자 및 물리적 특성

CAS No.	66532-85-2
분자식	C14H20N2O3
평균 분자량	264.32 g/mol
단동위원소 질량	264.1473925 g/mol
SMILES	CCN(CC)CC(=O)Oc1ccc(NC(C)=O)cc1
InChIKey	QTGAJCQTLIRCFL-UHFFFAOYSA-N
PubChem CID	68865
ChEMBL	CHEMBL1851805
ChEBI	CHEBI:135089
EC No.	266-390-1
DTXSID	DTXSID3057800

화학 및 물리적 성질

XLogP	1.1
극성 표면적	58.6
수소 결합 공여자 수	1
수소 결합 수용자 수	4
회전 가능 결합 수	7
무거운 원자 수	19
형식 전하	0
복잡도	295
물질 분류	Other Uses -> Pharmaceuticals
의약품	Pharmaceuticals -> Listed in ZINC15
용해도	SolubleH2O : 100 mg/mL (378.33 mMNeed ultrasonic)
끓는 점	434.5ºC at 760 mmHg434.5±30.0 °C(Predicted)
녹는점	55-57 °C
밀도	1.132±0.06 g/cm3(Predicted)
저장 조건	Store at -20°C
pKa(산도 계수)	14.20±0.70(Predicted)
물리적 상태	Solid
색상	White to off-white

안전 및 규제

유해성 요약	Allergic contact dermatitis reported in nurses (contact and airborne dermatitis)[Kanerva, p. 1829]
유해 작용	Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
Drug Induced Liver Injury	Drug-Induced Liver Injury Severity and Toxicity (DILIst)PropacetamolDILI PositiveDOI:10.1016/j.drudis.2019.09.022

용도

개요

Propacetamol is the prodrug of paracetamol (acetaminophen), used for intravenous administration. It results from eombination of paracetamol and diethylglycine. Causes contact dermatitis and airborne dermatitis in nurses. Allergenic properties are due to the N,N' -diethylglycine moiety, and not to the paracetamol moiety.

용도

Propacetamol hydrochloride is a water-soluble prodrug for intravenous administration resulting in the liberation of paracetamol.