3,3'-Diaminobenzidine (HCID 7071)

개요

3,3'-diaminobenzidine is a member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group. It has a role as a histological dye. It is a member of biphenyls and a substituted aniline.

이름 및 식별자

우선 이름: 3,3'-Diaminobenzidine
IUPAC: 4-(3,4-diaminophenyl)benzene-1,2-diamine
현지명: 3,3'-다이아미노벤지딘
영어명: 3,3'-Diaminobenzidine
분자식: C12H14N4
분자량: 214.27

이름 및 동의어

3,3'-Diaminobenzidine91-95-23,3-DIAMINOBENZIDINE3,3',4,4'-Tetraaminobiphenyl3,3',4,4'-Biphenyltetramine3,3',4,4'-Tetraaminodiphenyl3,3',4,4'-Diphenyltetramine3,3',4,4'-Tetraminobiphenyl[1,1'-Biphenyl]-3,3',4,4'-tetramine(1,1'-Biphenyl)-3,3',4,4'-tetramineDTXSID2036827Biphenyl-3,3',4,4'-tetrayltetraamine

이름 더 보기

3,3′-디아미노벤지딘3,3'-다이아미노벤지딘3,3'-디아미노벤지딘DABDIAMINOBENZIDINE[1,1'-biphenyl]-3,3',4,4'-tetraaMineTETRAAMINOBIPHENYL3,3'DAB BUFFERJACS-91-95-2TIMTEC-BB SBB0084273'-DiaMinobenzidine3,3'-Diaminobenzidin

2RV4T6KHQINSC-76152DTXCID0016827CHEBI:909943,3 Diaminobenzidine3,3' diaminobenzidineDiaminobenzidine, 3,3Diaminobenzidine, 3,3'

데이터베이스 식별자

CAS: 91-95-2
PubChem CID: 7071
DTXSID: DTXSID2036827
ChEMBL: CHEMBL1396955
ChEBI: CHEBI:90994
UNII: 2RV4T6KHQI
EC Number: 202-110-6
Nikkaji: J3.927F

물성

구조 계산 물성

XLogP: 0.9
극성 표면적: 104 Å²
수소 결합 공여자 수: 4
수소 결합 수용자 수: 4
회전 가능 결합 수: 1
무거운 원자 수: 16
형식 전하: 0
복잡도: 209

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Benzidine and Derivatives

LogP0.09

SolubilitySolubility in water: very poor

Flash Point>200 °C

Melting Point176 °C

Physical Description · 3건

Dry Powder

Red to brown hygroscopic solid; [ICSC]

RED-TO-BROWN HYGROSCOPIC SOLID IN VARIOUS FORMS.

물리화학적 성질

녹는점: 175 · 175-177 °C(lit.)
끓는 점: 344.41 °C · 344.41°C (rough estimate)
밀도: 1.1726 · 1.1726 (rough estimate)
굴절률: 1.5 · 1.5000 (estimate)
인화점: 12 °C · 12 °C
저장 조건: room temp
용해도: 0.55 g/L · 0.55g/L
물리적 상태: 태블릿 형태
산도 계수 (pKa): 4.39 · 4.39±0.10(Predicted)
색상: 메탄올에서 결정의 형성
수소이온지수(pH): 7 · 7 (1g/l, H2O, 20℃)
수용성: 0.55 g/L · 0.55g/L(20℃)
BRN: 1212988 · 1212988
안정성: 수분과 빛에 민감합니다. 강한 산화제와 호환되지 않습니다.
주요 응용: 진단 검사 제조혈액학조직학
InChI: 1S/C12H14N4/c13-9-3-1-7(5-11(9)15)8-2-4-10(14)12(16)6-8/h1-6H,13-16H2
InChIKey: HSTOKWSFWGCZMH-UHFFFAOYSA-N
SMILES: NC1=C(N)C=CC(C2=CC(N)=C(N)C=C2)=C1
NIST: 3 · 3,3'-Diaminobenzidine(91-95-2)
EPA: 3 · 3,3'-Diaminobenzidine (91-95-2)

화학적 성질

Off-white to brown solid.

안전 및 규제

GHS 분류

GHS Classification · 6건

Danger

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Danger

H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

유해성 정보

Regulatory Information · 2건

Hazard Traits - Carcinogenicity

[1,1'-Biphenyl]-3,3',4,4'-tetramine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of [1,1'-Biphenyl]-3,3',4,4'-tetramine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Fire HazardsCombustible.

Hazards Summary · 1건

Causes muscle weakness, cyanosis, and urine changes in inhalation lethal-dose study of rats; [RTECS] May cause eye irritation; A possible human carcinogen; [ICSC] May cause irritation; Possible teratogen and carcinogen; [Aldrich MSDS] See Benzidine.

Chemical DangersDecomposes on burning. This produces nitrogen oxides. Reacts with strong oxidants.

Hazard Classes and Categories · 3건

Muta. 2 (100%)

Carcinogenicity - category 1B

Carc. 1B

안전 및 보호

Fire FightingUse water spray, powder, alcohol-resistant foam, carbon dioxide.

First Aid Measures · 4건

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Safe StorageDry. Well closed. Separated from food and feedstuffs and strong oxidants. Store in an area without drain or sewer access.

Spillage Disposal · 1건

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Eye PreventionWear safety spectacles.

Fire PreventionNO open flames.

독성 정보

Exposure RoutesThe substance can be absorbed into the body in hazardous amounts by inhalation of its aerosol and by ingestion.

Signs and SymptomsRedness.

ICSC Environmental DataEnvironmental effects from the substance have not been investigated adequately.

Toxicity DataLCLo (rat) = 260 mg/m3/4hr

안전 데이터

wgk: 1
tsca: TSCA listed
rtecs: DV8750000
ridadr: UN 3316 9
독성: LDLo orl-rat: 3000 mg/kg CNREA8 26,619,66
HS 번호: 29214200
risk_code: 36/37/38-40-22-20/21/22-68-45-67-37-34-11-8
hazard_code: Xn,T,F,O
safety_code: 26-36/37-45-36/37/39-22-53-16
F 고인화성물질: 8-10-23
Hazard Classifications: Acute Tox. 4 OralCarc. 1BEye Irrit. 2Muta. 2
스토리지 클래스: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

화학 및 산업

용도 및 제조

UsesUsed as a reagent; [REPROTOX]

U.S. Production2023: 140,461 lb

Consumer UsesNot Known or Reasonably Ascertainable

Industry UsesNot Known or Reasonably Ascertainable

General Manufacturing Information · 2건

Textiles, apparel, and leather manufacturing

[1,1'-Biphenyl]-3,3',4,4'-tetramine: ACTIVE

응용 분야 · 2건

개요3,3'-Diaminobenzidine (DAB) is a precursor to polybenzimidazole. DAB is frequently used in the immunohistochemical staining of nucleic acids and proteins. It can also be used to detect fingerprints in blood because that it can be oxidized by hydrogen peroxide in the presence of hemoglobin to give a dark-brown color.

용도3,3'-Diaminobenzidine is used as peroxidase substrate and a reagent for spectrophotometric determination of selenium. DAB is used for the immunohistochemical staining of nucleic acids and proteins. As a dark brown dye, was used as an antibody-specific stain to identify the paired antibodies in breast tissue. It may be used for the synthesis of a useful, linear, Schiff-base coordination polymer.

제조 방법 · 1건

15 kg of 98.5% pure 3,3'-dinitro-4,4'-diaminobiphenyl tide product and 45 kg of methanol,0.075 kg of palladium carbon is mixed, and hydrogen gas of 0.85-0.9 MPa is introduced at 55-60 ° C, and stirred for 3 hours.At the end of the reaction, the catalyst was recovered, methanol was recovered, 30 kg of water was added, and the mixture was centrifuged and dried to obtain 9.3 kg of 3,3'-Diaminobenzidine having a purity of 99.3%.The yield was 90.6% (based on 3,3'-dinitro-4,4'-diacetylaminobiphenyl).

상·하류 제품 정보

상류 원료

벤지딘

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]

杭州创引化工科技有限公司0571-87086220 13516718938 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

추가 설명 · 1건

정의ChEBI: 3,3'-diaminobenzidine is a member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group. It has a role as a histological dye. It is a member of biphenyls and a substituted aniline.