3,3'-다이아미노벤지딘
3,3'-Diaminobenzidine
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기본 정보
- CAS
91-95-2- 표준 SMILES
Nc1ccc(-c2ccc(N)c(N)c2)cc1N- InChIKey
HSTOKWSFWGCZMH-UHFFFAOYSA-N- 분자식
- C12H14N4
- 평균 분자량
- 214.27 g/mol
- 단동위원소 질량
- 214.12184646
개요
3,3'-diaminobenzidine is a member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group. It has a role as a histological dye. It is a member of biphenyls and a substituted aniline.
이름 및 식별자
- 우선 이름
- 3,3'-Diaminobenzidine
- IUPAC
- 4-(3,4-diaminophenyl)benzene-1,2-diamine
- 현지명
- 3,3'-다이아미노벤지딘
- 영어명
- 3,3'-Diaminobenzidine
- 분자식
- C12H14N4
- 분자량
- 214.27
이름 및 동의어
3,3'-Diaminobenzidine91-95-23,3-DIAMINOBENZIDINE3,3',4,4'-Tetraaminobiphenyl3,3',4,4'-Biphenyltetramine3,3',4,4'-Tetraaminodiphenyl3,3',4,4'-Diphenyltetramine3,3',4,4'-Tetraminobiphenyl[1,1'-Biphenyl]-3,3',4,4'-tetramineBiphenyl-3,3',4,4'-tetrayltetraamine(1,1'-Biphenyl)-3,3',4,4'-tetramineDTXSID2036827
이름 더 보기
3,3′-디아미노벤지딘3,3'-다이아미노벤지딘3,3'-디아미노벤지딘DABDIAMINOBENZIDINE[1,1'-biphenyl]-3,3',4,4'-tetraaMineTETRAAMINOBIPHENYL3,3'DAB BUFFERJACS-91-95-2TIMTEC-BB SBB0084273'-DiaMinobenzidine3,3'-Diaminobenzidin
2RV4T6KHQIDiaminobenzidine, 3,3NSC-76152DTXCID0016827CHEBI:909943,3 Diaminobenzidine3,3' diaminobenzidineDiaminobenzidine, 3,3'
데이터베이스 식별자
- CAS
91-95-2- PubChem CID
- 7071
- DTXSID
DTXSID2036827- ChEMBL
CHEMBL1396955- ChEBI
CHEBI:90994- UNII
- 2RV4T6KHQI
- EC Number
- 202-110-6
- Nikkaji
- J3.927F
물성
구조 계산 물성보충 중
- XLogP
- 0.9
- 극성 표면적
- 104 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 16
- 형식 전하
- 0
- 복잡도
- 209
실험 및 물리화학적 성질
Chemical ClassesNitrogen Compounds -> Benzidine and Derivatives
LogP0.09
SolubilitySolubility in water: very poor
Flash Point>200 °C
Melting Point176 °C
Physical Description
Dry Powder
Red to brown hygroscopic solid; [ICSC]
RED-TO-BROWN HYGROSCOPIC SOLID IN VARIOUS FORMS.
Autoignition Temperature560 °C
물리화학적 성질
- 녹는점
- 175 · 175-177 °C(lit.)
- 끓는 점
- 344.41 °C · 344.41°C (rough estimate)
- 밀도
- 1.1726 · 1.1726 (rough estimate)
- 굴절률
- 1.5 · 1.5000 (estimate)
- 인화점
- 12 °C · 12 °C
- 저장 조건
- room temp
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Danger
H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
유해성 정보
Regulatory Information
Hazard Traits - Carcinogenicity
[1,1'-Biphenyl]-3,3',4,4'-tetramine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of [1,1'-Biphenyl]-3,3',4,4'-tetramine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Biphenyl-3,3',4,4'-Tetrayltetraamine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Fire HazardsCombustible.
Hazards Summary
Causes muscle weakness, cyanosis, and urine changes in inhalation lethal-dose study of rats; [RTECS] May cause eye irritation; A possible human carcinogen; [ICSC] May cause irritation; Possible teratogen and carcinogen; [Aldrich MSDS] See Benzidine.
Chemical DangersDecomposes on burning. This produces nitrogen oxides. Reacts with strong oxidants.
Hazard Classes and Categories
Muta. 2 (100%)
Carcinogenicity - category 1B
Carc. 1B
안전 및 보호
화학 및 산업
용도 및 제조
UsesUsed as a reagent; [REPROTOX]
U.S. Production2023: 140,461 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesNot Known or Reasonably Ascertainable
General Manufacturing Information
Textiles, apparel, and leather manufacturing
[1,1'-Biphenyl]-3,3',4,4'-tetramine: ACTIVE
응용 분야
개요3,3'-Diaminobenzidine (DAB) is a precursor to polybenzimidazole. DAB is frequently used in the immunohistochemical staining of nucleic acids and proteins. It can also be used to detect fingerprints in blood because that it can be oxidized by hydrogen peroxide in the presence of hemoglobin to give a dark-brown color.
용도3,3'-Diaminobenzidine is used as peroxidase substrate and a reagent for spectrophotometric determination of selenium. DAB is used for the immunohistochemical staining of nucleic acids and proteins. As a dark brown dye, was used as an antibody-specific stain to identify the paired antibodies in breast tissue. It may be used for the synthesis of a useful, linear, Schiff-base coordination polymer.
제조 방법
15 kg of 98.5% pure 3,3'-dinitro-4,4'-diaminobiphenyl tide product and 45 kg of methanol,0.075 kg of palladium carbon is mixed, and hydrogen gas of 0.85-0.9 MPa is introduced at 55-60 ° C, and stirred for 3 hours.At the end of the reaction, the catalyst was recovered, methanol was recovered, 30 kg of water was added, and the mixture was centrifuged and dried to obtain 9.3 kg of 3,3'-Diaminobenzidine having a purity of 99.3%.The yield was 90.6% (based on 3,3'-dinitro-4,4'-diacetylaminobiphenyl).
관련 반응
23건
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