벤지딘

벤지딘 · (1,1'-바이페닐)-4,4'-다이아민 · (1,1'-이페닐)-4,4'-디아민 · [1,1'-바이페닐]-4,4'-다이아민 · 4,4'-다이아미노바이페닐 · 4,4'-디아미노디페닐 · 4,4'-디페닐렌디아민 · 4,4'-바이페닐다이아민

https://huagongshe.com/ko/chemical/7111

식별자 및 물리적 특성

CAS No.	92-87-5
분자식	C12H12N2
평균 분자량	184.24 g/mol
단동위원소 질량	184.10004838 g/mol
SMILES	Nc1ccc(-c2ccc(N)cc2)cc1
InChIKey	HFACYLZERDEVSX-UHFFFAOYSA-N
PubChem CID	7111
ChEMBL	CHEMBL15901
ChEBI	CHEBI:80495
EC No.	202-199-1
DTXSID	DTXSID2020137
현지명	벤지딘

화학 및 물리적 성질

XLogP	1.3
극성 표면적	52
수소 결합 공여자 수	2
수소 결합 수용자 수	2
회전 가능 결합 수	1
무거운 원자 수	14
형식 전하	0
복잡도	145
물질 분류	Hazardous Air Pollutants (HAPs)Nitrogen Compounds -> Benzidine and DerivativesCarcinogensSemi-Volatile Organic Compound (SVOC)
SpringerMaterials Properties	Chemical structure
농약	Pesticide -> EPA IRIS
LogP(분배 계수)	log Kow= 1.341.53
밀도	2.15 at 68 °F (USCG, 1999) - Denser than waterwill sink1.250 @ 20 °C/4 °C1.3 g/cm³1.25 @ 20°C
Color/Form	White or slightly-reddish, crystalline powderGrayish-yellow, reddish-gray, or white crystalline powder [Note: Darkens on exposure to air and light].
용해도	less than 1 mg/mL at 72 °F (NTP, 1992)1 g dissolves in 2500 ml cold water1 g dissolves in 107 ml boiling water1 g dissolves in 5 ml boiling alcohol1 g dissolves in 50 ml etherIn water, 322 mg/l @ 25 °C0.322 mg/mL at 25 °CSolubility in water, g/100ml at 25 °C:(54 °F): 0.04%에탄올(US EPA, 1985) 및 에테르(1g/50mL)에 용해됨(Windholz et al., 1983)
끓는 점	752 °F at 740 mmHg (NTP, 1992)401 °C401 °C @760 [mm Hg]402°C
Decomposition	When heated to decomp it emits highly toxic fumes of /nitrogen oxides/.
녹는점	262 °F (NTP, 1992)120 °C127 °C239 °F127-128 °C
증기 밀도	6.36 (NTP, 1992) - Heavier than airwill sink (Relative to Air)6.36 (Air = 1)Relative vapor density (air = 1): 6.4
증기압	Low (NIOSH, 2024)0.0000009 [mmHg]Based on the specific vapor density value of 6.36 (Sims et al., 1988), the vapor pressure wascalculated to be 0.83 at 20 °C.
굴절률	1.6266 (estimate)
인화점	11 °C
저장 조건	2-8°C
pKa(산도 계수)	4.66(at 30℃)
색상	회황색의 결정성 분말흰색 또는 약간 붉은빛을 띠는 결정, 분말
용해도	거의 용해되지 않음. 22&C에서 <0.1g/100mL
Merck	13,1077
BRN	742770
헨리 상수	(x 10-11 atmm3/mol): 3.88 at 25 °C (estimated, Howard, 1989)
안정성	안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
InChIKey	HFACYLZERDEVSX-UHFFFAOYSA-N
NIST	Benzidine(92-87-5)
EPA	Benzidine (92-87-5)

화학적 성질

Benzidine is a white, grayish-yellow, or slightly reddish crystalline solid or powder. The major use for benzidine is in the production of dyes, especially azo dyes in the leather, textile, and paper industries, as a synthetic precursor in the preparation and manufacture of dyestuffs. It is also used in the manufacture of dyes and rubber, as a reagent, and as a stain in microscopy. It is slightly soluble and slowly changes from a solid to a gas.

안전 및 규제

GHS 분류	DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P203, P264, P270, P273, P280, P301+P317, P318, P330, P391, P405, and P501 (click each P-code to see the statement)H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
규제 정보	Chemical: [1,1'-Biphenyl]-4,4'-diamineS - indicates a substance that is identified in a final Significant New Use Rule.Restricted substance: Benzidine[1,1'-Biphenyl]-4,4'-diamine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보	IMAP assessments - [1,1'-Biphenyl]-4,4'-diamine: Environment tier I assessment
운송 라벨(DOT)	Poison
화재 위험	Special Hazards of Combustion Products: Contain highly toxic NOx fumes.· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
화재 가능성	Benzidine itself does not burn or burns with difficulty.
건강 유해성	Poisonous if inhaled, swallowed or absorbed through skin. May cause contact dermatitis, irritation or sensitization. Ingestion may cause nausea and vomiting. (USCG, 1999)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death.
유해성 요약	Benzidine is a manufactured chemical that does not occur naturally. It is a crystalline solid that may be grayish-yellow, white, or reddish-gray. In the environment, benzidine is found in either its "free" state (as an organic base), or as a salt. Benzidine was used to produce dyes for cloth, paper, and leather. It is no longer produced or used commerically in the U.S.Benzidine is no longer produced in the United States, although benzidine-based dyes may be imported into this country. No information is available on the acute (short-term) effects of benzidine in humans by inhalation exposure but benzidine is considered to be very acutely toxic to humans by ingestion. Chronic (long-term) exposure to benzidine in humans may result in injury to the bladder. Epidemiological studies have shown occupational exposure to benzidine to result in an increased risk of bladder cancer. Animal studies have reported various tumor types at multiple sites from benzidine exposure via oral, inhalation, and injection exposure. EPA has classified benzidine as a Group A, known human carcinogen.

용도

물감의 중간체, 화학 분석의 검출액 따위로 쓴다.

개요

Benzidine is a white, greyish-yellow, or slightly reddish crystalline solid or powder. The major use for benzidine is in the production of dyes, especially azo dyes in the leather, textile, and paper industries and as a synthetic precursor in the preparation and manufacture of dyestuffs. It is also used in the manufacture of rubber, as a reagent, and as a stain in microscopy. It is slightly soluble and slowly changes from a solid to a gas.

용도

Benzidine was used extensively in the manu facture of dyes. Because of its cancer-causingeffects in humans, its application in dyes hasbeen curtailed. Other uses of this compoundare in chemical analysis: as a reagent for thedetermination of hydrogen peroxide in milkand in the analysis of nicotine. Its hydrochlo ride is used as a reagent to analyze metalsand sulfate.

일반 설명

A grayish-yellow to grayish-red, crystalline solid. Toxic by ingestion, inhalation, and skin absorption. Combustion produces toxic oxides of nitrogen. Used to make other chemicals and in chemical and biological analysis.

제조 및 합성 방법

제조 방법

1-Nitrobenzene restore 1,2-Diphenylhydrazineturn with acid rearrangement.

생산 방법

Benzidine production is now exclusively for captive consumption and must be carried out in closed systems under stringent workplace controls. Benzidine is used in the synthesisofdyesanddyeintermediates,asahardenerforrubber, and as a laboratory reagent. The rst successful synthetic direct dye was Congo Red, a diazo derivative prepared from benzidinebyBoettigerin1884.Nearlyalldirectdyesareazo products. Congo Red is used in humans intravenously for the medical diagnosis of amyloidosis. The basis for its use is an unexplained afnity for amyloid, which rapidly removes the dye from the blood. It is used medically for the management of profuse capillary hemorrhage such as the one occurring in septicemias and in the terminal phases of leukemia.