Sec-Butyl acetate

log Kow = 1.72

1.51

1.72

HAS FRUITY ODOR CHARACTERISTIC OF ACETATE ESTERS

Pleasant fruity odor

0.872 at 68 °F (USCG, 1999) - Less dense than water; will float

0.8748 g/cu cm at 20 °C

Relative density (water = 1): 0.87

0.872

0.862-0.866 @ 20°C

0.86

0.8 % (NIOSH, 2024)

Miscible with alcohol and ether

Soluble ethanol, ethyl ether; slightly soluble in carbon tetrachloride

In water, 6200 mg/L at 20 °C

Solubility in water, g/100ml at 20 °C: 0.8

0.8%

62 °F (USCG, 1999)

31 °C

31 °C (88 °F) (open cup)

62 °F (closed cup)

17 °C c.c.

62 °F

234 °F at 760 mmHg (USCG, 1999)

112 °C

112 °C

234 °F

112 °C @760 [mm Hg]

234 °F

-100 °F (USCG, 1999)

-98.9 °C

-99 °C

-100 °F

-98.9 °C

-100 °F

Danger

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 4.9% (16 of 325) of reports.

Danger

H225 (94.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Acetic acid, 1-methylpropyl ester: HSNO Approval: HSR001093 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Highly flammable. Vapour/air mixtures are explosive.

Headaches, dizziness, nausea, irritation of respiratory passage and eyes. (USCG, 1999)

· May cause toxic effects if inhaled or absorbed through skin.

1123 129

1123 129

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 1/26/94; Reporting date: 3/28/94.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. sec-Butyl acetate is included on this list. Effective date: 1/26/94; Sunset date: 6/30/98.

Fire Extinguishing Agents Not to Be Used: Water may be ineffective

Use foam, alcohol-resistant foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Excerpt from NIOSH Pocket Guide for sec-Butyl acetate:

General First Aid:

(General first aid procedures)

To fight fire, use alcohol foam, CO2, dry chemical.

If material on fire or involved in a fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Butyl acetates/

Water may be ineffective on fire. Cool exposed containers with water.

Fire fighting: Use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS DUE TO CONTACT WITH HEAT, MOISTURE, ACIDS OR ACID FUMES, SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & ... PERIODICALLY INSPECTED & MONITORED.

1) Remove all ignition sources. 2) Ventilate area of spill or leak. 3) For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper towel in suitable location away from combustible materials. Large quantities may be collected & atomized in suitable combustion chamber. sec-Butyl acetate should not be allowed to enter a confined space, such as sewer, because of possibility of explosion.

/Absorb/ it in vermiculite, dry sand, earth or a similar material.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Apply appropriate foam to diminish vapor and fire hazard. /Butyl acetates/

Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Use surface active agent (eg detergent, soaps, alcohols), if approved by EPA. Inject "universal" gelling agent to solidify encircled spill and increased effectiveness of booms. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Butyl acetates/

Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Butyl acetates/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of sec-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 17 mm Hg(3), and water solubility, 6200 mg/L(4). sec-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 17 mm Hg(4), and water solubility, 6200 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5.4 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 6(SRC), from its log Kow of 1.72(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(9) suggests that biodegradation is an important environmental fate process in water(SRC). Hydrolysis is expected to occur slowly based upon estimated hydrolysis half-lives of 3.5 years and 128 days at pH 7 and 8, respectively(10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-butyl acetate, which has a vapor pressure of 17 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 70 hours(SRC), calculated from its rate constant of 5.5X10-12 cu cm/molecule-sec at 25 °C(3). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The substance can be absorbed into the body by inhalation of its vapour.

inhalation, ingestion, skin and/or eye contact

Cough. Sore throat. Dizziness. Headache.

Dry skin.

Redness.

Nausea.

irritation eyes; headache; drowsiness; dryness upper respiratory system, skin; narcosis

Using a structure estimation method based on molecular connectivity indices(1), the Koc of sec-butyl acetate can be estimated to be 16(SRC). According to a classification scheme(2), this estimated Koc value suggests that sec-butyl acetate is expected to have very high mobility in soil.

/HUMAN EXPOSURE STUDIES/ A study of sensory irritation (nasal pungency) associated with a series of homologous ketones and secondary and tertiary alcohols and esters was conducted. The study group consisted of three men and one woman, 41 to 65 years old, who lacked a sense of smell (anosmics) and three men and one woman 41 to 68 years old, with normal olfaction (normosmics). The subjects were exposed to 2-propanone (67641), 2-pentanone (107879), 2-heptanone (110430), 2-nonanone (821556), 2-propanol (67630), 2-methyl-2-propanol (75650), 2-butanol (78922), 4-heptanol (589559), tert-butyl-acetate (540885), and sec-butyl-acetate (105464) vapors at concentrations of 1x10-2 to 1x10+6 ppm by sniffing bottles containing the solvents. They also sniffed bottles containing a blank (nonodoriferous solvent). The subjects were asked to estimate the concentration of each solvent at which they could first detect the odor and perceive nasal pungency. Attempts were made to correlate the thresholds with the concentration of the saturated vapor at ambient temperature (23 °C). Both the normosmics and anosmics could detect the solvent vapors; however, the normosmics detected the vapors at much lower concentrations. The nasal pungency and odor thresholds of the ketones decreased with increasing carbon chain length, but tended to plateau at 2-heptanone. The odor and pungency thresholds of the alcohols tended to increase when the hydroxy group was changed from a primary to a secondary carbon atom. The odor and pungency thresholds of the esters were similar. When plotted against the logarithm of the saturation vapor concentration, the logarithm of the pungency thresholds of the compounds conformed to a linear function that was approximately parallel to the saturation vapor concentration. No association between odor threshold and saturation vapor concentration was seen. The authors conclude that anosmics as well as normosmics can detect odors of volatile organic compounds, although at different concentrations. The pungency threshold data suggest that physical rather than chemical factors are involved in the interaction of volatile organic compounds with the nasal mucosa.

/SIGNS AND SYMPTOMS/ Overexposure to sec-butyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness. Prolonged overexposure may produce irritation of the skin.

/SIGNS AND SYMPTOMS/ Vapors cause slight smarting of the eyes or resp system if present in high concn. ... If spilled on clothing and allowed to remain may cause smarting and reddening of the skin.

/SIGNS AND SYMPTOMS/ In man, exposure to concentrations of 950 ppm for 30 min causes irritation of the nose and eyes, headaches and weakness. The principal symptoms in cases of occupational exposure are headaches and irritation of the mucous membranes of the nose and of the conjunctiva. Other symptoms mentioned include vertigo, palpitations, gastrointestinal disorders, anaemia, cutaneous lesions, dermatitis and affections of the liver.

For more Human Toxicity Excerpts (Complete) data for SEC-BUTYL ACETATE (6 total), please visit the HSDB record page.

... Volatiles formed during fringe process and during a continuous process of malt vinegar manufacture /were measured/. ... sec-Butyl acetate ... was detected during the /initial/ alcoholic fermentation.

sec-Butyl acetate's production and use as a solvent for nitrocellulose lacquers, thinners and leather finishes(1) may lead to its release to the environment through various waste streams(SRC).

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 1/26/94; Reporting date: 3/28/94.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. sec-Butyl acetate is included on this list. Effective date: 1/26/94; Sunset date: 6/30/98.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

sec-Butyl acetate is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Used as a solvent (nitrocellulose lacquers, thinners, nail enamels, leather finishes); [ACGIH]

Pulp and Paper Processing [Category: Industry]

Solvent for nitrocellulose lacquers, thinners, nail enamels, leather finishes

(1972) 9.7X10+9 GRAMS (ALL BUTYL ACETATES)

(1975) 5.99X10+9 GRAMS (ALL BUTYL ACETATES)

(1972) 2.0X10+7 GRAMS (ALL BUTYL ACETATES)

(1975) 3.22X10+8 GRAMS (ALL BUTYL ACETATES)

(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS

(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#1955]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Acetic acid, 1-methylpropyl ester. Aggregated National Production Volume: < 500,000 pounds.

Prepared from sec-butanol and acetic anhydride.

Prepared from 2-butene under pressure and heated to 115-120 °C with an excess of glacial acetic acid containing 10% sulfuric acid

Esterification of sec-butyl alcohol