2-메톡시에틸 아세테이트

Pleasant odor

Ester-like odor

1.006 at 68 °F (USCG, 1999) - Denser than water; will sink

1.0074 g/cu cm at 19 °C

Bulk density: 8.4 lb/gal at 20 °C

Relative density (water = 1): 1.01

1.006

1.005 @ 20°C

greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

Hildebrand solubility parameter(delta) = 18.8 MPa; Coefficient of expansion = 0.00110 °C-1 at 20 °C

Miscible with most organic solvents, oils

Very soluble in water, ethyl ether, and ethanol; soluble in carbon tetrachloride.

Infinitely soluble in water at 25 °C; water infinitely soluble in methyl cellosolve acetate at 25 °C

Solubility in water: miscible

111 °F (NTP, 1992)

111 °F

45 °C (120 °F) (CLOSED CUP)

55.6 °C (Open cup)

45 °C c.c.

120 °F

293 °F at 760 mmHg (NTP, 1992)

145 °C

145 °C

293 °F

143 °C @760 [mm Hg]

293 °F

-85 °F (NTP, 1992)

-65.1 °C

-65 °C

-85 °F

-70 °C

-85 °F

4.07 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.1 (Air = 1)

Relative vapor density (air = 1): 4.1

4.07

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]；H312: Harmful in contact with skin [Warning Acute toxicity, dermal]；H332: Harmful if inhaled [Warning Acute toxicity, inhalation]；H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]

P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)

Danger

Chemical: Ethanol, 2-methoxy-, acetate

Hazard Traits - Developmental Toxicity; Reproductive Toxicity；Authoritative List - EC Annex VI CMRs - Cat. 1B; OEHHA RELs; Prop 65；Report - regardless of intended function of ingredient in the product

S - indicates a substance that is identified in a final Significant New Use Rule.

Substance: 2-methoxyethyl acetate；EC: 203-772-9；Date of inclusion: >16-Jul-2019；Reason for inclusion: Toxic for reproduction (Article 57c)

Ethanol, 2-methoxy-, acetate: HSNO Approval: HSR001160 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon monoxide, may be formed when involved in fire. (USCG, 1999)

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.；· Vapors may form explosive mixtures with air.；· Vapors may travel to source of ignition and flash back.；· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).；· Vapor explosion hazard indoors, outdoors or in sewers.；· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.；· Runoff to sewer may create fire or explosion hazard.；· Containers may explode when heated.；· Many liquids will float on water.

Flammable. Above 45 °C explosive vapour/air mixtures may be formed.

May cause irritation if splashed into eyes. Can be absorbed through the skin. Swallowing a large single dose or absorbing larged amount through skin could result in death. It is unlikely that air levels of the compound would be dangerous unless it is heated. (USCG, 1999)

· May cause toxic effects if inhaled or absorbed through skin.；· Inhalation or contact with material may irritate or burn skin and eyes.；· Fire will produce irritating, corrosive and/or toxic gases.；· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.；· Runoff from fire control or dilution water may cause environmental contamination.

After repeated 8-hour exposures to 200-1000 ppm, animals show evidence of kidney and bone marrow damage. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Potential adverse effects include injury to the bone marrow, kidneys, and CNS (unconsciousness). May be a reproductive toxin and defat the skin; [ICSC] See Glycol ethers.

1189 129

1189 129

European Chem Indust Ecol Tox Centre; The Toxicology of Ethylene glycol monoalkyl ethers and its Relevance to Man. (6/30/92)

Toxicity to Man of Ethylene glycol monoalkyl ethers. Cahiers de notes documentaires - Securite et hygiene du travail 2nd quarter (1983) p 215-30 (No 111, Note No 1422-111-83).

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:；CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.；SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).；LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.；FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.；· Keep unauthorized personnel away.；· Stay upwind, uphill and/or upstream.；· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.；· All equipment used when handling the product must be grounded.；· Do not touch or walk through spilled material.；· Stop leak if you can do it without risk.；· Prevent entry into waterways, sewers, basements or confined areas.；· A vapor-suppressing foam may be used to reduce vapors.；· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.；· Use clean, non-sparking tools to collect absorbed material.；Large Spill；· Dike far ahead of liquid spill for later disposal.；· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:；· Call 911 or emergency medical service.；· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.；· Move victim to fresh air if it can be done safely.；· Administer oxygen if breathing is difficult.；· If victim is not breathing:；-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.；-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).；-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.；· Remove and isolate contaminated clothing and shoes.；· For minor skin contact, avoid spreading material on unaffected skin.；· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.；· For severe burns, immediate medical attention is required.；· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.；· Keep victim calm and warm.；· Keep victim under observation.；· For further assistance, contact your local Poison Control Center.；· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.；Specific First Aid:；· Wash skin with soap and water.

(General first aid procedures)；Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.；Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.；Breathing: Respiratory support；Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

· Wear positive pressure self-contained breathing apparatus (SCBA).；· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - 2-Methoxyacetic acid in urine = 1 mg/g creatinine; end of shift at end of workweek; [ACGIH]

1.0 [ppm], sum of concentrations of CAS 109-86-4 and its acetate in air[German Research Foundation (DFG)]

To fight fire, use CO2, dry chemical.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME...TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN SUITABLE COMBUSTION CHAMBER. LIQ...SHOULD NOT BE ALLOWED TO ENTER CONFINED SPACE, SUCH AS SEWER, BECAUSE OF POSSIBILITY OF EXPLOSION.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.；LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL & DISPOSING IN SECURED SANITARY LANDFILL. 2. BY ATOMIZING IN SUITABLE COMBUSTION CHAMBER.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static bioassay in fresh water at 23 °C, mild aeration applied after 24 hr; Concentration: 45 ppm for 96 hr

LC50; Species: Menidia beryllina /(Inland silverside)/; Conditions: static bioassay in synthetic seawater at 23 °C, mild airation applied after 24 hr; Concentration: 40 ppm for 96 hr

LC50; Species: Carassius auratus (Goldfish, weight 3.3 g); Conditions: freshwater, static, 20 °C, pH 7.0, dissolved oxygen >4.0 mg/L; Concentration: 190000 ug/L for 24 hr

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from an estimated log Kow of 0.10(2) and a regression-derived equation(3), indicates that methyl cellosolve acetate is expected to have very high mobility in soil(SRC). Volatilization of methyl cellosolve acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg at 20 °C(4), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). The potential for volatilization of methyl cellosolve acetate from dry soil surfaces may exist(SRC) based on its vapor pressure(4). Using aqueous screening tests methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days(6,7), suggesting that biodegradation may be an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from an estimated log Kow of 0.10(2) and a regression-derived equation(3), indicates that methyl cellosolve acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg(4), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 24 days and 270 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3.2(3), from an estimated log Kow(2), and a regression derived equation(7) suggests that bioconcentration in aquatic organisms is low(SRC). Hydrolysis half-lives of 140 and 14 days at pH values of 7 and 8, respectively(10), suggest that hydrolysis is not expected to be an important process except under basic conditions(SRC). Using aqueous screening tests, methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days(8,9), suggesting that biodegradation may be an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl cellosolve acetate, which has a measured vapor pressure of 7.0 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl cellosolve acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 1.1 days(SRC) calculated from its rate constant of 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC)that was derived using a structure estimation method(3). Methyl cellosolve acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Neurotoxin - Acute solvent syndrome；Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.；Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.；Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studied than that of 2-MEA and 2-EEA. 2-ME and 2-EE and their acetates have similar lethalities after single exposures and they show low acute lethality whether exposure is via the dermal, oral, or inhalation route. Oral LD60 values for a variety of species range between 900 and 3400 mg/kg body weight for 2-ME, 1400 and 5500 mg/kg for 2-EE, 1250 and 3930 mg/kg for 2-MEA, and 1300 and 5100 mg/kg for 2-EEA. ... Short-term inhalation exposure (up to 90 days) of experimental animals to high concentrations (> 9313 mg 2-ME/cu m ... has been shown to lead to adverse effects on blood parameters, the nervous system, and testes, thymus, kidney, liver, and lung. At lower exposure levels, effects are observed on the hemopoietic system and testes. For example, rats exposed by inhalation to 2-ME for 13 week

/AQUATIC SPECIES/ Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L ...

Dizziness. Drowsiness. Headache.

MAY BE ABSORBED! Dry skin. Further see Inhalation.

Redness.

Abdominal pain. Nausea. Vomiting. Weakness. Unconsciousness. Further see Inhalation.

irritation eyes, nose, throat; kidney, brain damage; In Animals: narcosis; reproductive, teratogenic effects

The Koc of methyl cellosolve acetate is estimated as approximately 30(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that methyl cellosolve acetate is expected to have very high mobility in soil(SRC).

Chemical: Ethanol, 2-methoxy-, acetate

Hazard Traits - Developmental Toxicity; Reproductive Toxicity；Authoritative List - EC Annex VI CMRs - Cat. 1B; OEHHA RELs; Prop 65；Report - regardless of intended function of ingredient in the product

S - indicates a substance that is identified in a final Significant New Use Rule.

Substance: 2-methoxyethyl acetate；EC: 203-772-9；Date of inclusion: >16-Jul-2019；Reason for inclusion: Toxic for reproduction (Article 57c)

Ethanol, 2-methoxy-, acetate: HSNO Approval: HSR001160 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monomethey ether acetate is produced, as an intermediate or a final product, by process units covered under this subpart.

...Must be .../hydrolyzed/ by body because it gives rise to toxic signs similar to those caused by ethylene glycol methyl ether. Some acetaldehyde may also be formed.

The ester hydrolyzes in body to 2-methoxyethanol.

EGMEA is readily metabolized in mouse nasal tissues to produce EGME. EGME is further metabolized by alcohol dehydrogenase to 2-methoxyacetic acid, a known reproductive and developmental toxicant.

The in vitro nasal mucosal carboxylesterase activity of mice was compared to the activity of other mice tissues and to the nasal mucosal carboxylesterase activity of rats, rabbits, or dogs when exposed to 2-MEA or 2-EEA. The specific activity in nasal carboxylase was found to be similar to that of the liver in mice, but it was greater than the activity found in the kidney, lung, or blood of mice. Nasal mucosal carboxyl-esterase activity of mice was comparable to that of dogs, slightly higher than the activity in rats, and nearly six-fold higher than the activity in rabbits. These in vitro studies suggest that considerable hydrolysis may occur in the intact animal, resulting in the formation of acetic acid at the initial route of entry.

Used as a solvent and in the production of photographic films and textile printing; [ACGIH]

The Semiconductor Industry Association recommends elimination of this solvent because of potential reproductive effects. [CHS, p. 43]

Semiconductor Manufacturing [Category: Industry]；Textiles (Printing, Dyeing, or Finishing) [Category: Industry]

Solvent for nitrocellulose, cellulose acetate, various gums, resins, waxes, oils; textile printing; photographic film; lacquers; dopes

Used in silkscreening inks

Industrial solvent

(1972) LESS THAN 4.54X10+9 GRAMS

1,000,000 pounds (1983)

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#514]