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HCID 8114생성일: 2026년 10월 27일

디노르말프로필에테르

다이프로필에테르 · 디노르말프로필에테르 · 디프로필에테르 · 디프로필에테르,산화디프로필 · 다이프로필 에테르 · n-프로필에테르 · DIPROPYL ETHER · DI-N-PROPYL ETHER

https://huagongshe.com/ko/chemical/8114

디노르말프로필에테르 분자 구조식

식별자 및 물리적 특성

CAS No.111-43-3
분자식C6H14O
평균 분자량102.17 g/mol
단동위원소 질량102.10446507 g/mol
SMILESCCCOCCC
InChIKeyPOLCUAVZOMRGSN-UHFFFAOYSA-N
PubChem CID8114
ChEMBLCHEMBL3187166
EC No.203-869-6
DTXSIDDTXSID8042343
현지명디노르말프로필에테르

화학 및 물리적 성질

XLogP2
극성 표면적9.2
수소 결합 공여자 수0
수소 결합 수용자 수1
회전 가능 결합 수4
무거운 원자 수7
형식 전하0
복잡도23
LogP(분배 계수)log Kow = 2.03
밀도0.7466 at 20 °C/4 °CRelative density (water = 1): 0.70.736 g/mL at 25 °C(lit.)
Color/FormMobile liquid
용해도Soluble in alcohol, etherIn water, 4.9X10+3 mg/L at 25 °CSolubility in water, g/100ml at 25 °C: 0.25H2O: 약간 용해됨
인화점70 °F (NFPA, 2010)70 °F (21 °C) (Closed cup)21 °C c.c.40 °F
끓는 점89-91 °C88-90 °C88-90 °C(lit.)
DecompositionWhen heated to decomposition it emits acrid smoke and irritating fumes.
녹는점-122 °C-123 °C
증기 밀도3.53 (Air =1)Relative vapor density (air = 1): 3.53
증기압62.5 [mmHg]62.5 mm Hg at 25 °CVapor pressure, kPa at 25 °C: 8.3355 mm Hg ( 20 °C)
굴절률Index of refraction: 1.3807 at 20 °C/Dn20/D 1.380(lit.)
헨리 상수Henry's Law constant = 2.2X10-3 atm-cu m/mole at 25 °C2.9×10-3 mol/(m3Pa) at 25℃, Brockbank (2013)
저장 조건Flammables area
물리적 상태액체
색상무색의
용해도물 3g/L(20°C)에 약간 용해되며 알코올과 에테르에 용해됩니다.
비열Cp(liquid): 2.17 J/(g·K), at 25℃
Merck14,7857
BRN1731312
유전율3.4(26℃)
InChI1S/C6H14O/c1-3-5-7-6-4-2/h3-6H2,1-2H3
InChIKeyPOLCUAVZOMRGSN-UHFFFAOYSA-N
SMILESCCCOCCC
EPAPropyl ether (111-43-3)

화학적 성질

CLEAR COLOURLESS LIQUID

안전 및 규제

GHS 분류DangerH225: Highly Flammable liquid and vapor [Danger Flammable liquids]H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposureNarcotic effects]P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
규제 정보Chemical: Propane, 1,1'-oxybis-Propane, 1,1'-oxybis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propane, 1,1'-oxybis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Propane, 1,1'-oxybis-: HSNO Approval: HSR001139 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
운송 라벨(DOT)Flammable Liquid
화재 위험Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)· Vapors may form explosive mixtures with air.· Vapors may travel to source of ignition and flash back.· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Vapor explosion hazard indoors, outdoors or in sewers.

용도

용도

Di-n-propyl ether, is used as a solvent and intermediate for organic chemical synthesis.

일반 설명

A colorless liquid with a strong odor. Less dense than water and slightly soluble in water. Flash point of 70°F. Vapors are heavier than air. In high concentrations the vapors may be narcotic.

· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.
· Runoff to sewer may create fire or explosion hazard.
· Containers may explode when heated.
· Many liquids will float on water.
Flammable. Above 21 °C explosive vapour/air mixtures may be formed.
화재 가능성EXTREMELY FLAMMABLE.A flammable liquid and dangerous fire hazard when exposed to heat, flame, or oxidizers.ONLY ELECTRICAL EQUIPMENT OF EXPLOSION-PROOF TYPE (GROUP C CLASSIFICATION) IS PERMITTED TO BE OPERATED IN ETHER AREAS. ETHER SHOULD NOT BE STORED NEAR POWERFUL OXIDIZERS OR IN AREAS OF HIGH FIRE HAZARD. /ETHERS/
건강 유해성Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)· Inhalation or contact with material may irritate or burn skin and eyes.· Fire may produce irritating, corrosive and/or toxic gases.· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.· Runoff from fire control or dilution water may cause environmental contamination.
유해성 요약Has anesthetic effects[ICSC]
운송 번호 및 가이드(DOT)2384 127
반응성 그룹Ethers
EC 분류Symbol: FR: 11-19-66-67S: (2)-9-16-29-33Note: C
UN 분류UN Hazard Class: 3UN Pack Group: II
Reactivity AlertsHighly FlammablePeroxidizable Compound
Reactivity ProfileEthers, such as DI-N-PROPYL ETHER, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
소화Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Use foam, dry powder, carbon dioxide. NO water. In case of fire: keep drums, etc., cool by spraying with water.
응급 조치Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth.
누출 비상 조치· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· All equipment used when handling the product must be grounded.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· A vapor-suppressing foam may be used to reduce vapors.· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.· Use clean, non-sparking tools to collect absorbed material.Large Spill· Dike far ahead of liquid spill for later disposal.· Water spray may reduce vapor, but may not prevent ignition in closed spaces.
응급 처치Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· Wash skin with soap and water.
안전 보관Fireproof. Cool. Keep in the dark.
노출 관리 및 개인 보호· Wear positive pressure self-contained breathing apparatus (SCBA).· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.
소화 절차If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Do not extinguish fire unless flow can be stopped. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.
보관 조건Fireproof. Cool. Keep in the dark.
정리 방법Cover the spilled material with dry earth, sand or other non-combustible material. Collect leaking liquid in sealable containers. Remove all ignition sources. Ventilation. Do NOT wash /spill/ away ... (Extra personal protection: filter respirator for organic gases and vapors.)
비화재 누출 대응Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)
처리 방법SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations./This compound should be susceptible to removal from waste water by air stripping. /Bis(2-chloroethyl)ether/
누출 처리Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Do NOT wash away into sewer. Cover the spilled material with dry earth, sand or other non-combustible material. Collect leaking and spilled liquid in sealable containers as far as possible.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a structure estimation method(2), indicates that propyl ether is expected to have very high mobility in soil(SRC). Volatilization of dipropyl ether from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 2.2X10-3 atm-cu m/mole(3). Volatilization of dipropyl ether from dry soil surfaces is expected(SRC) based upon a vapor pressure of 62.5 mm Hg(4). Limited biodegradation data(5,6) suggest that dipropyl ether may be biodegraded in soil if acclimated microbial populations are present(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a structure estimation method(2), indicates that propyl ether is not expected to adsorb to suspended solids and sediment in the water column(SRC). Dipropyl ether is expected to volatilize from water surfaces(3) based on a Henry's Law constant of 2.2X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), estimated volatilization half-lives for a model river and model lake are 3.6 hours and 4.1 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 7(SRC), from log Kow of 2.03(6), and a regression derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Following a lag period of 13 days, dipropyl ether reached 63% of its theoretical BOD after 25 days incubation in an activated sludge aqueous screening study(8). In another activated sludge screening test dipropyl ether did not biodegrade in 240 hours(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dipropyl ether, which has a vapor pressure of 62.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dipropyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals(SRC)half-lives for these reactions in air are estimated to be 21 hours and 4.9 days, respectively(3,4). Direct photolysis is not expected to be an important removal process since aliphatic ethers do not absorb light in the environmental UV spectrum(5).
유해 작용Neurotoxin - Acute solvent syndrome
노출 경로The substance can be absorbed into the body by inhalation.
Signs and SymptomsCough. Sore throat. Dizziness. Headache.Redness. Pain. Dry skin.
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc for dipropyl ether can be estimated to be about 15(SRC). According to a classification scheme(2), this estimated Koc value suggests that dipropyl ether is expected to have very high mobility in soil(SRC).
Artificial Pollution SourcesDipropyl ether can be used for the same purposes as diethyl ether(1), which is used primarily as a solvent(2). Dipropyl ether's use as a solvent may result in its release to the environment through various waste streams(SRC).
Environmental BiodegradationAEROBIC: An activated sludge aqueous screening study found that dipropyl ether was biodegraded quickly after a 13 day lag period with a 63% theoretical biological oxygen demand being measured after 25 days incubation(1). In another activated sludge screening test dipropyl ether was not biodegraded within 240 hours(2). Many ethers are known to be resistant to biodegradation(3).ANAEROBIC: 0% loss of dipropyl ether was observed in landfill leachate impacted aquifer slurries amended with sulfate or nitrate after 244 and 85 days incubation, respectively(1). Dipropyl ether was not biodegraded in aquifer slurries prepared from the methanogenic portion of a shallow anoxic aquifer polluted by municipal landfill leachate(2).
Environmental BioconcentrationAn estimated BCF of 7 was calculated for dipropyl ether(SRC), using a log Kow of 2.03(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.
Volatilization from Water/SoilThe Henry's Law constant for dipropyl ether is 2.2X10-3 atm-cu m/mole(1). This Henry's Law constant indicates that dipropyl ether is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is approximately 3.4 hours(SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is approximately 4.1 days(SRC). Dipropyl ether's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). Volatilization of dipropyl ether from dry soil surfaces is expected(SRC) based upon a vapor pressure of 62.5 mm Hg(3).
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Acute Exposure/ The sensory irritating response of propyl ether (PE) on respiratory rate was measured in mice. Male CF-1-mice were anesthetized and allowed to recover before exposure. In the first experiment, the irritating effect of airborn chemicals on the trigeminal nerve ends was investigated by observing for reflex induced decrease in the respiratory rate and for the characteristic respiratory patterns. In the second study, the effect on the vagus nerve was investigated by observing for reflex induced decrease in the respiratory rate and for the respiratory patterns. PE was delivered at a rate from 2,400 to 60,000 ppm in an exposure chamber. Each animal was placed in a body plethysmograph attached to the exposure chamber whereby the head protruded from the chamber. The respiratory pattern of each animal was displayed on an oscillograph. Concentration response relationships were obtained by plotting the percentage decrease in the average respiratory rate of each groupfrom these relationships the concentration expected to cause a 50% decrease in respiratory rate (RD50) due to sensory irritation was estimated. At a concentration of 15,000 ppm or less, the sensory irritation response disappeared after approximately 1 min. The average respiratory rate also decreased within the first minute. For the sensory irritation response the threshold and the RD50 were about 620 and 89,000 ppm, respectivelythe sensory irritating concentration needed to depress the respiratory rate to 50% could not be reached with saturated vapor at 20 °C. At concentrations >15,000 ppm, the sensory irritation response disappeared within 30 sec and was replaced with patterns characteristic for pulmonary irritation or anesthesia. .../LABORATORY ANIMALS: Acute Exposure/ The effects of propyl-ether(PE) on pulmonary irritation and anesthesia were investigated in mice. Each animal was placed in a body plethysmograph attached to the exposure chamber so that the head of the animal protruded into the chamber. The change in tidal volume was obtained from a 10 sec sample once every 1, 2, 5, or 10 min. The respiratory pattern of each animal was displayed on an oscillograph, and the average respiratory rate of each group of four mice was continuously displayed. Exposure to PE was for 30 or 240 min followed by 20 min of recovery. Changes in tidal volume were calculated from the first 10 sec in every experiment. Four mice were given pentobarbitol anesthesia ip and observed on the plethysmograph for the next 240 minchanges in tidal volume were obtained from a 10 sec sample every 10 min. The anesthetic effect of PE was revealed by observing escape activity (body movement) of the mice in the plethysmograph and observing absence of righting reflex at the end of the recovery period. Distinction between changes in respiratory rate and tidal volume due to anesthesia or pulmonary irritation was obtained by comparison of the responses at equal anesthesia concentrations caused by propyl-ether and pentobarbital. After cessation of the sensory irritation response, a mixed response due to pulmonary irritation and anesthesia appeared, resulting in a decrease in respiratory rate and tidal volume. In cannulated mice the decrease in respiratory rate was introduced more slowly. Shortly after injection of pentobarbitol, the respiratory rate decreased in a dose dependent mannerthe maximum decrease was found within 10 to 60 minutes. All mice given pentobarbital lost righting reflex at 35 and 50 mg/kg. ...
Environmental Abiotic DegradationThe rate constant for the vapor-phase reaction of dipropyl ether with photochemically-produced hydroxyl radicals is 1.85X10-11 cu cm/molecule-sec at 25 °C(1). This rate constant corresponds to an atmospheric half-life of about 21 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). Direct photolysis is not expected to be an important removal process since aliphatic ethers do not absorb light in the environmental spectrum(2). The rate constant for the reaction of dipropyl ether with nitrate radicals is 6.49X10-15 cu cm/molecule-sec at 22 °C(3). This corresponds to an atmospheric half-life of about 4.9 days at an average atmospheric concentration of 5X10+8 nitrate radicals per cu cm(4). Dipropyl ether is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(5).
Probable Routes of Human ExposureOccupational exposure to dipropyl ether may occur through inhalation and dermal contact with this compound at workplaces where dipropyl ether is used. (SRC)
수질 위해 등급(WGK)1
TSCA 등재 상태TSCA listed
RTECS 번호UJ5125000
운송 번호(UN)UN 2384
관세 코드29091990
위험 문구(R)11-19-66-67
위험 표시F
안전 문구(S)9-16-29-33
포장분류II
위험 등급3Flam. Liq. 2STOT SE 3
기존화학 물질KE-27716
저장 분류3 - Flammable liquids
유해 물질 데이터111-43-3(Hazardous Substances Data)