Bistris (HCID 81462)

개요

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris.

이름 및 식별자

우선 이름: Bistris
IUPAC: 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
현지명: 비스-트리스
영어명: BIS-Tris
분자식: C8H19NO5
분자량: 209.24

이름 및 동의어

bis-tris6976-37-0Bistris2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diolQ1XC3631CPCHEBI:412501,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-NSC-24868NSC-1199321,3-Propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-

이름 더 보기

2-(비스(2-하이드록시에틸)이미노)-2-하이드록시메틸)-1,3-프로판디올비스-트리스비스-하이드록시에틸트로메타민2,2-비스(히드록시메틸)-2,2',2"-니트릴로트리에탄올BIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANEBIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANEBIS-TRIS BUFFERBIS-HYDROXYETHYL TROMETHAMINEBis-Iris2,2-BIS(HY''BIS-TRIS''BIS-TRIS >99%

2,2-Bis[hydroxymethyl]-2,2',2''-nitrilotriethanolRefChem:569580bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)METHANE230-237-7686-880-2Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane

데이터베이스 식별자

CAS: 6976-37-0
PubChem CID: 81462
DTXSID: DTXSID6064537
ChEBI: CHEBI:41250
UNII: Q1XC3631CP
EC Number: 230-237-7、686-880-2
Nikkaji: J135.733F

물성

구조 계산 물성

XLogP: -3.3
극성 표면적: 104 Å²
수소 결합 공여자 수: 5
수소 결합 수용자 수: 6
회전 가능 결합 수: 8
무거운 원자 수: 14
형식 전하: 0
복잡도: 125

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other

Physical Description · 2건

Liquid

White crystalline powder; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점: 104 °C · 104 °C(lit.)
끓는 점: 466.2 · 466.2±40.0 °C(Predicted)
밀도: 1.346 · 1.346±0.06 g/cm3(Predicted)
증기압: 0 Pa · 0Pa at 25℃
저장 조건: Inert atmosphere,Room Temperature
용해도: 2 O: · H2O: 1 M at 20 °C, 투명, 무색
물리적 상태: 액체
색상: 노란색에서 주황색으로
냄새: 냄새 없는
수소이온지수(pH): 9 · 9.0-10.1 (20-25℃, 1M in water)
산도 계수 (pKa): 6.5 · 6.5(at 25℃)
생물학적 소스: synthetic
수용성: 녹는
BRN: 2205275 · 2205275
주요 응용: 진단 검사 제조
화장품 원료 기능: 버퍼링
InChI: 1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
InChIKey: OWMVSZAMULFTJU-UHFFFAOYSA-N
SMILES: OCCN(CCO)C(CO)(CO)CO
LogP: -2.26 at · -2.26 at 20℃
EPA: 1 · 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- (6976-37-0)
Absorption: 270 nm · cut-off at 270nm in H2O at 1M

화학적 성질

White/clear crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 0.7% (2 of 271) of reports.

Danger

H315 (37.6%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 271 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

유해성 정보

Regulatory Information · 4건

Chemical: 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 04-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/24579

1,3-Propanediol, 2-bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS]

Hazard Classes and Categories · 2건

Skin Irrit. 2 (37.6%)

Skin Irrit. 2 (100%)

안전 데이터

wgk: 3
tsca: TSCA listed
HS 번호: 29221980
risk_code: 36/37/38-21/22-20/21/22
hazard_code: Xi,Xn
safety_code: 26-36-36/37/39-22
기존화학 물질: KE-20636
F 고인화성물질: 10-23
Hazard Classifications: Eye Irrit. 2
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationA chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

용도 및 제조

U.S. Production2023: 362,371 lb

Industry UsesNot Known or Reasonably Ascertainable

General Manufacturing Information · 2건

Pharmaceutical and Medicine Manufacturing

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-: ACTIVE

응용 분야 · 2건

용도It is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.

용도Bis-Tris, also known as bis-Tris methane, is a zwitterionic buffering agent used in biochemistry and molecular biology. It is a bis(2-hydroxyethyl)amine and Tris family buffer. Bis Tris is a common component of many buffer systems for various types of electrophoresis. Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions. Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.