Chloroacetyl chloride → 2-Chloro-N-pyridin-2-yl-acetamide
반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1.C(N(C(C)C)CC)(C)C>ClCCl>[Cl:1][CH2:2][C:3]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[O:4]참가 물질
5
실험 절차
Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.
후처리
- customthe temperature below 5° C
- filtrationwas filtered
- washwashed with water
- dry with materialThe organic layer was dried (MgSO4)
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-3287b7f0e07644e393371b77d33adaf0
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723464
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