2,6-디클로로톨루엔

Fresh air, rest.

Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Chlorotoluenes/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Remove vapour with fine water spray.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. /Chlorotoluenes/

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Chlorotoluenes/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 5,100(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), indicates that 2,6-dichlorotoluene will be immobile in soil(SRC). Volatilization of 2,6-dichlorotoluene may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 4.2X10-3 atm-cu m/mole(SRC), using a recommended regression equation(4), and from dry soil surfaces(SRC) based on an estimated vapor pressure of 0.36 mm Hg(SRC), using a fragment constant method(5). Based on limited data, 2,6-dichlorotoluene may be resistant to biodegradation under anaerobic conditions(SRC). 2,6-Dichlorotoluene, at 1000 uM, was not readily biodegraded in an anoxic soil slurry; 30-35% biodegradation was reached after 150 days(6).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 5,100(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(1), indicates that 2,6-dichlorotoluene should adsorb to suspended solids and sediment in water(SRC). 2,6-Dichlorotoluene may volatilize from water surfaces based on an estimated Henry's Law constant of 4.2X10-3 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Estimated half-lives for a model river and model lake are 4 hours and 5 days, respectively(1,SRC). An estimated BCF value of 1,100(1,SRC), from a measured log Kow(2), suggests that 2,6-dichlorotoluene will bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(4). Based on limited data, 2,6-dichlorotoluene may be resistant to biodegradation under anaerobic conditions(SRC). 2,6-Dichlorotoluene, at 1000 uM, was not readily biodegraded in an anoxic soil slurry; 30-35% biodegradation was reached after 150 days(5).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,6-dichlorotoluene, which has an estimated vapor pressure of 0.36 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,6-dichlorotoluene is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 12 days(3,SRC).

In a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWS) sponsored by the Effluent Guidelines Division of the USEPA, 2,6-dichlorotoluene was identified in discharges of the following industrial category (frequency of occurrence, median concn in ppb): organic chemicals (14; 26.7), publicly owned treatment works (5; 40.4)(1). The highest effluent concn was 1424 ppb in the paint and ink industry(1).

The Koc of 2,6-dichlorotoluene is estimated as approximately 5,100(SRC), using a measured log Kow of 4.29(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that 2,6-dichlorotoluene will be immobile in soil(SRC).

Bacterial strains isolated from a landfill site previously used for disposal of chlorinated organic wastes were able to utilize 2,6-dichlorotoluene(1). 2,6-Dichlorotoluene, at 1000 uM, was not readily biodegraded in an anoxic soil slurry; 30-35% biodegradation was reached after 150 days(2).

An estimated BCF value of 1100 was calculated for 2,6-dichlorotoluene(SRC), using a measured log Kow of 4.29(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will occur(SRC).

The Henry's Law constant for 2,6-dichlorotoluene is estimated as 4.2X10-3 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 2,6-dichlorotoluene will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 5 days(2,SRC). This rate may be attenuated by adsorption to sediment and particulate matter in the water(SRC). 2,6-Dichlorotoluene's estimated values for vapor pressure, 0.36 mm Hg(3,SRC), and Henry's Law constant(1,SRC) indicate that volatilization from dry and moist soil surfaces may occur(SRC).

A method was developed to analyze rat tissue, fat and blood for some chlorinated compounds found in an extract of soil from an industrial waste site. Extraction with hexane and ethyl ether-hexane (1 + 1) was followed by concentration over steam, and gas chromatographic analysis with an electron capture detector. Volatile compounds were analyzed in a glass column coated with 6% SP-2100 plus 4% OV-ll on Chromosorb W. Semivolatile compounds, chlorinated compounds and pesticides were analyzed in a 70 m glass capillary column coated with 5 OV-101. Phenols were analyzed in a glass column packed with 1% SP-1240 DA on Supelcoport. The most efficient means of separation was to use the same glass column for volatile compounds, a DB-5 fused silica capillary column for semivolatile compounds, pesticides and phenols, and the same 1% SP-1240 DA glass column for separation of beta-BHC and pentachlorophenol. Recoveries ranged from 86.3 + or - 9.1% (mean + or - SD) to 105 + or - 10.4%. Sensitivities for semivolatile chlorinated compounds, pesticides and phenols were 4 ng/g for fat, 1 ng/g for tissue and 0.2 ng/ml for blood. Sensitivities for volatile compounds were 4-fold higher (16, 4 and 0.8, respectively). Sensitivities for dichlorobenzenes and dichlorotoluenes were 8 ng/g for fat, 2 ng/g for tissue and 0.4 ng/ml for blood.

2,6-Dichlorotoluene reacts with photochemically-produced hydroxyl radicals in the atmosphere by addition to the aromatic ring and H-atom abstraction. The rate constant for the vapor-phase reaction of 2,6-dichlorotoluene with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). 2,6-Dichlorotoluene has an absorption band at 274 nm that extends to about 300 nm(2); it is therefore a candidate for direct photolysis by sunlight. No information concerning photolysis rates could be found; however on irradiation with shorter UV light in dry, nitrogen purged methanol, rapid dehalogenation occurs(3).