오소 포름산 메틸

Trimethyl orthoformate

HCID 9005CAS 149-73-5

기본 정보

표준 SMILES
COC(OC)OC
InChIKey
PYOKUURKVVELLB-UHFFFAOYSA-N
분자식
C4H10O3
평균 분자량
106.12 g/mol
단동위원소 질량
106.06299418

이름 및 식별자

우선 이름
Trimethyl orthoformate
IUPAC
trimethoxymethane
현지명
오소 포름산 메틸
영어명
Trimethoxymethane
분자식
C4H10O3
분자량
106.12

이름 및 동의어

TrimethoxymethaneTRIMETHYL ORTHOFORMATE149-73-5Methyl orthoformateMethane, trimethoxy-MethoxymethylalOrthoformic acid methyl esterOrthoformic acid, trimethyl esterOrthomravencan methylnatyOrthoformic acid trimethyl esterMethylester kyseliny orthomravenciNSC 147479
이름 더 보기
오소포름산메틸트리메틸오르토포름염트리메틸오르토포름염TMOFCH(OCH3)3ch(ome)3Trimethyl esterThrimethyl orthoformateorthoformicacidmethylesterTrimethylorthoformiatTrimethyl orthoformate,99%
DTXSID7027122HSDB 1006Orthomravencan methylnaty [Czech]Trimethylester kyseliny orthomravenciEINECS 205-745-7BRN 0969215XAM28819YJMethylester kyseliny orthomravenci [Czech]

데이터베이스 식별자

CAS
149-73-5
PubChem CID
9005
DTXSID
DTXSID7027122
ChEMBL
CHEMBL3187679
UNII
XAM28819YJ
EC Number
205-745-7
Nikkaji
J8.664I

물성

구조 계산 물성

XLogP
0.2
극성 표면적
27.7 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
3
회전 가능 결합 수
3
무거운 원자 수
7

실험 및 물리화학적 성질

Chemical ClassesOther Classes -> Ethers, Other
SpringerMaterials PropertiesSchoenflies notation
OdorPUNGENT ODOR
Density · 2건

0.9676 @ 20 °C/4 °C

0.9676 @ 20°C

Color/FormCOLORLESS LIQUID
SolubilitySOL IN ETHANOL, IN ETHER

물리화학적 성질

녹는점
-53 °C · -53 °C
끓는 점
101 · 101-102 °C(lit.)
밀도
0.97 g/mL · 0.97 g/mL at 25 °C(lit.)
증기 밀도
3.67 · 3.67 (vs air)
증기압
23.5 mm · 23.5 mm Hg ( 20 °C)
굴절률
20 · n20/D 1.379(lit.)
화학적 성질 · 1건

Colorless liquid. Slightly soluble in water, miscible with alcohol and oils.Very diffusive, ethereal, pungent or nauseating odor, pleasant in dilution, slightly wineyfruity, Brandy-like.Sweet taste in concentrations below 100 ppm. Barely perceptible at 10 ppm.

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 0.7% (2 of 294) of reports.

Danger

H225 (99.3%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 294 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

유해성 정보

Regulatory Information · 4건

Chemical: Methane, trimethoxy-

Methane, trimethoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methane, trimethoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 08-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/12626

Trimethyl orthoformate: Does not have an individual approval but may be used under an appropriate group standard

Fire PotentialSLIGHT, WHEN EXPOSED TO HEAT OR FLAME; CAN REACT WITH OXIDIZING MATERIALS.
Hazards Summary · 1건

A skin, eye, and mucous membrane irritant; [HSDB] Findings in lethal dose animal experiments include cyanosis, loss of muscle tone, and unresponsiveness. [ToxPlanet: IUCLID] Hydrolyzed by water producing methanol; An irritant; [MSDSonline] See Methyl alcohol.

Hazard Classes and Categories · 2건

Flam. Liq. 2 (99.3%)

Flammable liquids - Category 2

Explosive Limits and PotentialSEE CHLOROFORM: UNPUBLISHED INFORMATION (1948). DURING ATTEMPTED PREPN OF TRIMETHYL ORTHOFORMATE, ADDITION OF SODIUM TO AN INADEQUATELY COOLED CHLOROFORM-METHANOL MIXTURE CAUSED VIOLENT EXPLOSION.

안전 및 보호

Protective Action Criteria (PAC) · 3건

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

독성 정보

Adverse EffectsNeurotoxin - Other CNS neurotoxin
Human Toxicity ExcerptsAN IRRITANT TO SKIN, EYES, & MUCOUS MEMBRANES.
Toxicity DataLC50 (rat) = 40,000 mg/m3

안전 데이터

wgk
1
tsca
TSCA listed
rtecs
RM6650000
ridadr
UN 3272 3/PG 2
독성
LD50 orally in Rabbit: 3130 mg/kg
HS 번호
29159080

화학 및 산업

용도 및 제조

U.S. Production2023: 1,323 lb
Consumer UsesOther
Industry UsesIntermediate
Methods of Manufacturing/IT IS/ PREPARED FROM CHLOROFORM AND METHANOL IN PRESENCE OF SODIUM: SAH, MA, J AM CHEM SOC 54, 2965 (1932).
General Manufacturing Information · 2건

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing

Methane, trimethoxy-: ACTIVE

응용 분야 · 3건

개요Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.

용도Trimethyl Orthoformate is the most simple orthoester. Used in organic synthesis as a reagent for introducing a protecting group for aldehydes and in the creation of methoxymethylene groups and heterocyclic ring systems.

일반 설명Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南京一化生物科技有限公司13429882898; 13429882898
淄博创谷化工科技有限公司00-15864498288 15864498288 · [email protected]

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