Propylamine → 5-Amino-1-propyl-1H-imidazole-4-carboxamide
반응식
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([NH2:5])=[O:4].[CH3:8]OC(OC)OC.[CH2:15]([NH2:18])[CH2:16][CH3:17]>C(#N)C>[NH2:7][C:6]1[N:18]([CH2:15][CH2:16][CH3:17])[CH:8]=[N:1][C:2]=1[C:3]([NH2:5])=[O:4]참가 물질
5
실험 절차
A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.
후처리
- temperaturewas heated
- temperatureunder reflux for 0.75 hour
- temperatureto cool
- customThe solid which precipitated
- filtrationwas collected by filtration
- customcrystallised from methanol
출처 및 근거
- ORD 기록
- ord-12e40ee7e23541c4b9a7cdf8dcd80cd1
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05734053
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