식별자 및 물리적 특성
| CAS No. | 1402-82-0 |
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| 분자식 | C58H91N13O20 |
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| 평균 분자량 | 1,290.437 g/mol |
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| 단동위원소 질량 | 1,289.65033231 g/mol |
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| SMILES | CCC(C)CCCCC/C=C/CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)[C@@H]1NC(=O)[C@H]2CCCCN2C1=O)C(C)C)[C@H](C)N)[C@@H](C)C(=O)O |
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| InChIKey | XBNDESPXQUOOBQ-LSMLZNGOSA-N |
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| PubChem CID | 91663250 |
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| ChEMBL | CHEMBL2103921 |
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| EC No. | 215-760-0 |
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| DTXSID | DTXSID101017657 |
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| 현지명 | 암포마이신 |
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화학 및 물리적 성질
| 끓는 점 | 854.06°C (rough estimate) |
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| 밀도 | 1.0985 (rough estimate) |
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| 굴절률 | 1.6700 (estimate) |
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| 저장 조건 | Store at -20°C |
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| 용해도 | DMSO에 용해됨 |
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| 물리적 상태 | 고체 |
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| 색상 | 크리스탈 |
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안전 및 규제
| 독성 | LD50 orl-mus: 500 mg/kg 85GDA2 4(1),317,80 |
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용도
용도
Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.
