트리스(하이드록시메틸)아미노메탄 수화염화물
Tromethamine hydrochloride
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기본 정보
- CAS
1185-53-1- 표준 SMILES
Cl.NC(CO)(CO)CO- InChIKey
QKNYBSVHEMOAJP-UHFFFAOYSA-N- 분자식
- C4H11NO3.ClH
- 평균 분자량
- 157.59 g/mol
- 단동위원소 질량
- 157.05057092
이름 및 식별자
- 우선 이름
- Tromethamine hydrochloride
- IUPAC
- 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
- 현지명
- 트리스(하이드록시메틸)아미노메탄 수화염화물
- 영어명
- TRIS hydrochloride
- 분자식
- C4H12ClNO3
- 분자량
- 157.6
이름 및 동의어
1185-53-1Tris hydrochlorideTris(hydroxymethyl)aminomethane hydrochlorideTromethamine hydrochloride2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochlorideTRIS HClTris-HClTrometamol hydrochlorideTrizma hydrochlorideTromethamine HCl1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideTris chloride
이름 더 보기
트리스(하이드록시메틸)아미노메탄수화염화물트리스(하이드록시메틸)아미노메탄수화염화물2-아미노-2-(히드록시메틸)-1,3-프로판디올염산염Tris-HCITRIS-HCL BUFFERTris-HCTRIS-HC1Tris hydrochloric acid
DTXSID4044373Tris hydrochloride bufferUNII-383V75M34EEINECS 214-684-5383V75M34E2-Amino-2-hydroxymethyl-1,3-propanediol hydrochlorideDTXCID2024373TROMETAMOL HYDROCHLORIDE [WHO-DD]
데이터베이스 식별자
- CAS
1185-53-1- PubChem CID
- 93573
- DTXSID
DTXSID4044373- ChEMBL
CHEMBL3183206- UNII
- 383V75M34E
- EC Number
- 214-684-5
물성
구조 계산 물성보충 중
- 극성 표면적
- 86.7 Ų
- 수소 결합 공여자 수
- 5
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 9
- 형식 전하
- 0
- 복잡도
- 54
실험 및 물리화학적 성질
Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other
Physical Description
Dry Powder; Liquid; Other Solid; Dry Powder
Hygroscopic solid; [Sigma-Aldrich MSDS]
물리화학적 성질
- 녹는점
- 150 · 150-152 °C
- 끓는 점
- 225 ℃[at · 225℃[at 101 325 Pa]
- 밀도
- 1.05 g/mL · 1.05 g/mL at 20 °C
- 증기압
- 0 Pa · 0Pa at 20℃
- 저장 조건
- room temp
- 용해도
- 2 O: · H2O: 4 M at 20 °C, 투명, 무색
- 물리적 상태
- 수정 같은
- 색상
- 투명한 무색(H2O에서 40 %(w/w)) 용액
- 수소이온지수(pH)
- 2.5 · 2.5-4.0 (25℃, 4M in H2O)
- 산도 계수 (pKa)
- 8.1 · 8.1(at 25℃)
- 생물학적 소스
- synthetic
- 수용성
- 녹는
- BRN
- 3675235 · 3675235
- 안정성
- 안정적인. 강한 산화제, 염기, 습기와 호환되지 않습니다.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 57.2% (103 of 180) of all reports.
Warning
H315 (42.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 180 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 09-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19306
2-amino-2-(hydroxymethyl)propane-1,3-diol: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA mild eye irritant in rabbits; Not a sensitizer in experimental animals; [Sigma-Aldrich MSDS] See Tromethamine.
Hazard Classes and CategoriesSkin Irrit. 2 (42.2%)
안전 및 보호
Protective Action Criteria (PAC)
18 [mg/m3]
190 [mg/m3]
1200 [mg/m3]
화학 및 산업
용도 및 제조
UsesUsed to make surface-active agents and pharmaceuticals, as an emulsifier (for cosmetic creams and lotions, mineral oil, and paraffin wax emulsions), as a biological buffer, and as an alkalizer; [ChemIDplus]
U.S. Production2023: 400,000 - <550,000 lb
Consumer UsesStabilizing agent
Industry UsesOther
General Manufacturing Information
All Other Chemical Product and Preparation Manufacturing
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1): ACTIVE
응용 분야
개요Abbreviated as Tris HCl (TRIS hydrochloride), Tris (hydroxymethyl) aminomethane hydrochloride is an organic compound commonly utilized in buffer solutions such as TAE or TBE for electrophoresis gels. It boasts high solubility in water and offers utility within the pH range of 7.0-9.0.
용도Tris Hydrochloride is a buffering medium for electrophoresis, molecular biology, and cell culture applications. It may be combined with Tris Base to simplify Tris buffer preparation. Tris Hydrochloride has been incorporated in coelomic fluid and in Cortland medium to store unfertilized rainbow trout eggs. In immunohistochemistry, Tris Hydrochloride has also been used with urea as a method for antigen retrieval.
일반 설명TRIS hydrochloride is mainly required for preparation of buffer at physiological range of 7.3 to 7.5. The prepared buffer is compatible with biological fluids. It is of importance to laboratories as a standard pH solution.
제조 방법
The preparation of TRIS hydrochloride is as follows:After reacting 2-amino-1,3-propanediol (2.50 g, 27.44 mmol) and formic acid (1.26 g, 27.44 mmol) in 50 ml of water at room temperature for 3 hours, water was distilled off under reduced pressure, A liquid was obtained. By washing the obtained liquid,An ammonium formate salt (3.76 g, 27.44 mmol) was obtained as a colorless transparent liquid.
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