1-Fluoronaphthalene (HCID 9450)

개요

1-fluoronaphthalene appears as needles. (NTP, 1992)

이름 및 식별자

우선 이름: 1-Fluoronaphthalene
IUPAC: 1-fluoronaphthalene
영어명: 1-Fluoronaphthalene
분자식: C10H7F
분자량: 146.16

이름 및 동의어

1-FLUORONAPHTHALENE321-38-0Naphthalene, 1-fluoro-alpha-Fluoronaphthalene0920702UT7NSC-4690DTXSID7059808RefChem:75827DTXCID1038454206-287-0Fluoronaphthalene.alpha.-Fluoronaphthalene

이름 더 보기

48720-uuoronaphthaLDuloxetine-81-FluoronaphthFluorophthalene

Duloxetine EP Impurity G1-fluoro naphthalene1-FluornaftalenDuloxetine IMpurity GNSC 46901-fluoronapthaleneEINECS 206-287-01-fluoro-naphtalene

데이터베이스 식별자

CAS: 321-38-0
PubChem CID: 9450
DTXSID: DTXSID7059808
UNII: 0920702UT7
EC Number: 206-287-0
Nikkaji: J9.228B

물성

구조 계산 물성

XLogP: 3.7
극성 표면적: 0 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 1
회전 가능 결합 수: 0
무거운 원자 수: 11
형식 전하: 0
복잡도: 133

실험 및 물리화학적 성질

PolymersOther Classes -> Halogenated Polyaromatics

SpringerMaterials Properties13C nuclear magnetic resonance spectrum

Density1.1322 at 68 °F (NTP, 1992) - Denser than water; will sink

Boiling Point419 °F at 756 mmHg (NTP, 1992)

Melting Point16 °F (NTP, 1992)

Vapor Pressure0.09 [mmHg]

물리화학적 성질

녹는점: -13 °C · -13 °C (lit.)
끓는 점: 215 °C · 215 °C (lit.)
밀도: 1.1322 g/mL · 1.1322 g/mL at 20 °C (lit.)
굴절률: 20 · n20/D 1.593(lit.)
인화점: 150 °F · 150 °F
저장 조건: Sealed in dry,Room Temperature
용해도: 물에 약간 용해되고 클로로포름, 에틸 아세테이트 및 메탄올에 잘 용해됩니다.
물리적 상태: 기름
색상: 무색~황색
Specific Gravity: 1.332 · 1.332
수용성: 물에 섞이거나 혼합하기 어렵지 않습니다.
BRN: 1906413 · 1906413
안정성: 안정적인. 강한 산화제와 호환되지 않습니다.
InChI: 1S/C10H7F/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H
InChIKey: CWLKTJOTWITYSI-UHFFFAOYSA-N
SMILES: Fc1cccc2ccccc12
NIST: 1 · Naphthalene, 1-fluoro-(321-38-0)
EPA: 1 · 1-Fluoronaphthalene (321-38-0)

화학적 성질

clear slightly yellow to yellow-brown liquid

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 5.5% (3 of 55) of reports.

Warning

H315 (94.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 55 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Naphthalene, 1-fluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Naphthalene, 1-fluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18128

DOT LabelPoison

Fire HazardsExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Health HazardsExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Hazards SummaryA skin and strong eye irritant; [Alfa Aesar MSDS] See Naphthalene.

Reactive GroupFluorinated Organic Compounds

안전 및 보호

Fire FightingA fire in your laboratory involving this chemical should be extinguished with a dry chemical, carbon dioxide or halon extinguisher. (NTP, 1992)

First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Personal Protective Equipment (PPE) · 1건

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: QJ7100000
ridadr: UN2810
HS 번호: 29039990
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36
위험 등급: IRRITANT
위험 참고 사항: Flammable
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스: 10 - Combustible liquids

화학 및 산업

용도 및 제조

U.S. Production2023: <50,000 lb

Industry UsesNot Known or Reasonably Ascertainable

General Manufacturing Information · 2건

All Other Basic Organic Chemical Manufacturing

Naphthalene, 1-fluoro-: ACTIVE

응용 분야

용도1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.

제조 방법 · 1건

The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.

상·하류 제품 정보

하류 제품

4-Fluoronaphtalene-1-boronic acid 2-(1-Fluoronaphthalen-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine 둘록세틴 3-브로모-1-플루오로나프탈렌 (S)-(+)-N,N-디메틸-3-(1-나프탈레닐옥시)-3-(2-티에닐)프로판아민 2-(1-나프틸렌)-4,4,5,5-테트라메틸-1,3,2-디옥사보롤란 1-fluoro-2-iodonaphthalene 4-Fluoronaphthalene-1-sulfonyl chloride (S)-N,N-Dimethyl-[3-(2-thienyl)-3-(1-naphthyloxy)propyl]amine--phosphoric acid (1:1)3-브로모-1-플루오로-2-요오도나프탈렌 (S)-N,N-Dimethyl-[3-(2-thienyl)-3-(1-naphthyloxy)propyl]amine--phosphoric acid (1:1)

공급사50 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

T&W GROUP021-61551611 13296011611 · [email protected]

연결된 노트

불러오는 중…

1-Fluoronaphthalene

기본 정보

개요