Acetic Acid → 1-(Chloromethyl)-4-fluoronaphthalene

HRID 8205

반응식

HRID 8205 반응식
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.C=O.P(=O)(O)(O)O.[ClH:19].[C:20](O)(=O)C>O>[Cl:19][CH2:20][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([F:1])=[CH:3][CH:4]=1

참가 물질

7

반응물 5

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 1004Phosphoric AcidHCID 94501-Fluoronaphthalene

생성물 1

HCID 156574171-(Chloromethyl)-4-fluoronaphthalene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1-fluoronaphthalene (5.5 g, 37.6 mmol), paraformaldehyde (2.5 g, 83 mmol), glacial acetic acid (3.5 mL), phosphoric acid (2 mL) and concentrated hydrochloric acid (5 mL) is heated at 85° C. for 15 h. The reaction mixture is poured into water and extracted three times with dichloromethane. The organic extracts are combined and washed with water and brine, dried (sodium sulfate), filtered, and evaporated to yield the title compound, 6.53 g (98%, as a yellow solid.

후처리

  1. extractionextracted three times with dichloromethane
  2. washwashed with water and brine
  3. dry with materialdried (sodium sulfate)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-eb6b605148f94f1c8e3a24b3c564aca0
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087626B2

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