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스페르미딘 트리하이드로클로라이드

Spermidine trihydrochloride

HCID 9539
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
334-50-9
표준 SMILES
Cl.Cl.Cl.NCCCCNCCCN
InChIKey
LCNBIHVSOPXFMR-UHFFFAOYSA-N
분자식
C7H22Cl3N3
평균 분자량
254.6 g/mol
단동위원소 질량
253.087931

개요

Spermidine trihydrochloride is an organic molecular entity. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is functionally related to a spermidine.

이름 및 식별자

우선 이름
Spermidine trihydrochloride
IUPAC
N'-(3-aminopropyl)butane-1,4-diamine;trihydrochloride
현지명
스페르미딘 트리하이드로클로라이드
영어명
Spermidine trihydrochloride
분자식
C7H22Cl3N3
분자량
254.63

이름 및 동의어

Spermidine trihydrochloride334-50-9Spermidine hydrochlorideSpermidine HClN-(3-Aminopropyl)-1,4-butanediamine trihydrochlorideEINECS 206-379-0NSC 5283991,4-BUTANEDIAMINE, N-(3-AMINOPROPYL)-, TRIHYDROCHLORIDE1O14BED3981,4-Butanediamine, N-(3-aminopropyl), hydrochloride4-Azoniaoctamethylenediammonium trichlorideNSC-528399
이름 더 보기
스페르미딘트리하이드로클로라이드스퍼미딘 트라이하이드로클로라이드SPERMIDINE 3HCLN-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDESpermidie 3HCLSPD·3HClSperMidine triSPERMIDINE 3HCSperpmidine HCLSpermidine 3HCl>98%
SPERMIDINE TRIHYDROCHLORIDE [MI]1,4-Butanediamine, N1-(3-aminopropyl)-, hydrochloride (1:3)RefChem:888501SPERMIDINE HCL [INCI]4Azoniaoctamethylenediammonium trichlorideN(3Aminopropyl)1,4butanediamine trihydrochloride1,4Butanediamine, N(3aminopropyl), hydrochloride1,4Butanediamine, N(3aminopropyl), trihydrochloride

물성

구조 계산 물성

극성 표면적
64.1 Ų
수소 결합 공여자 수
6
수소 결합 수용자 수
3
회전 가능 결합 수
7
무거운 원자 수
13
형식 전하
0
복잡도
56.8

실험 및 물리화학적 성질

Chemical ClassesOther Uses -> Biochemical Research
Physical DescriptionSolid; [Merck Index] White hygroscopic powder; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점
257 · 257-259 °C(lit.)
저장 조건
room temp
용해도
2 O: · H2O: 1 M at 20 °C, 투명, 무색
물리적 상태
결정성 분말
색상
하얀색
수소이온지수(pH)
3 · 3.0-6.0 (25℃, 1M in H2O)
생물학적 소스
microbialsynthetic
수용성
물(100 mg/ml) 및 에탄올에 용해됩니다.
BRN
3552356 · 3552356
화장품 원료 기능
헤어 컨디셔닝
InChI
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
InChIKey
LCNBIHVSOPXFMR-UHFFFAOYSA-N
SMILES
C(CCCN)NCCCN.Cl.Cl.Cl
EPA
1 · 1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9)

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazards SummaryCauses convulsions in acute intraperitoneal studies of rats and mice; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
EJ7023000
HS 번호
29212900
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36
F 고인화성물질
3-10
Hazard Classifications
Eye Irrit. 2Skin Irrit. 2
스토리지 클래스
11 - Combustible Solids

화학 및 산업

용도 및 제조

UsesFound widely in nature and essential for tissue growth; Used as a tool in biochemical research; [Merck Index]
General Manufacturing Information1,4-Butanediamine, N1-(3-aminopropyl)-, hydrochloride (1:3): ACTIVE
응용 분야 · 3건

개요Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

용도Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

일반 설명Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

공급사100 곳

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山东科立康药业有限公司053-88113608 17854192669
山东天微医药科技有限公司+86-18653895227 · [email protected]

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화합물 노트

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이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트

데이터베이스 식별자

CAS
334-50-9
PubChem CID
9539
DTXSID
DTXSID0059825
ChEMBL
CHEMBL1256356、CHEMBL1473196
ChEBI
CHEBI:233088
UNII
1O14BED398
EC Number
206-379-0

화학적 성질

Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.

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