CAS 51022-70-9 Salbutamol Sulfate (HCID 9884233)

이름 및 식별자

우선 이름: Salbutamol Sulfate
IUPAC: 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;sulfuric acid
현지명: 알부테롤 황산염
영어명: Albuterol sulfate
분자식: C13H23NO7S
분자량: 337.39

이름 및 동의어

Salbutamol sulfateRefChem:1098298(1RS)-2-(1,1-Dimethylethyl)amino-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol hemisulfate51022-70-939971-61-44-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol sulfateAlbuterol sulfate(1:x);34245-12-04-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; sulfuric acidSMR000058513Albuterol sulfate(1:x)alpha-([t-Butylamino]methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol

이름 더 보기

알부테롤황산염알부테롤황산염(ALBUTEROLSULFATE)SALBUTAMOL SULPHATEALBUTEROL SULPHATESULBUTAMOL SULFATEAlbuterol hemisulfateSALBUTAMOL HEMISULFATE(R,S)-Salbutamol Sulphate1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanolsulfateMozalVolma

CPD000058513Salbutamol hemisulphate saltSCHEMBL33280MLS000758199MLS001423971orb1222141CHEMBL1201026OVICLFZZVQVVFT-UHFFFAOYSA-N

데이터베이스 식별자

CAS: 51022-70-9
PubChem CID: 9884233
ChEMBL: CHEMBL1201026
EC Number: 256-916-8

물성

구조 계산 물성

극성 표면적: 156 Å²
수소 결합 공여자 수: 6
수소 결합 수용자 수: 8
회전 가능 결합 수: 5
무거운 원자 수: 22
형식 전하: 0
복잡도: 309

물리화학적 성질

녹는점: 180 °C · 180 °C
인화점: 250 °C · 250 °C
저장 조건: 2 · 2-8°C
용해도: 1 M · 1 M NaOH: 가용성 50 mg/ml, 투명하거나 약간 흐릿함, 황록색
물리적 상태: Solid
색상: 하얀색
수용성: 1 M · 물과 1M 수산화나트륨(50mg/ml)에 용해됩니다.
Merck: 216 · 216
BCS Class: 1 · 1
주요 응용: 임상 연구법의학 및 독성학의약품(소분자)
InChI: InChI=1S/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
InChIKey: OVICLFZZVQVVFT-UHFFFAOYSA-N
SMILES: CC(C)(NCC(O)C1C=CC(O)=C(CO)C=1)C.S(O)(O)(=O)=O

화학적 성질

Albuterol sulfate is a white or practically white powder, freely soluble in water and slightly soluble in ethanol.

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (20.9%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P270, P272, P280, P301+P317, P302+P352, P318, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 110 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Other Safety InformationIMAP assessments - 1,3-Benzenedimethanol, .alpha.1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, sulfate (2:1) (salt): Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (20.9%)

안전 데이터

wgk: 3
rtecs: ZE4400000
ridadr: 2811
HS 번호: 29225090
risk_code: 43-22
hazard_code: Xn,Xi
safety_code: 36/37-36
기존화학 물질: KE-11364
Hazard Classifications: Carc. 2Repr. 2Skin Sens. 1
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

응용 분야 · 3건

개요Albuterol sulfate (Brand name: PROVENTIL® HFA) is the sulfate form of albuterol which is also known as salbutamol. It is a kind of short-acting, selective beta2-adrenergic receptor agonist being capable of opening up the medium and large airways in the lungs. It is mainly used for the treatment of bronchospasm (induced by bronchial asthma or exercise) as well as chronic obstructive pulmonary disease (COPD). Albuterol sulfate takes effects through directly biding to the beta (2)-adrenergic receptors in the lung and causing relaxation of bronchial smooth muscles. This relaxation is mediated by its effect of stimulating cAMP production through activating adenylate cyclase, further inhibiting the phosphorylation of myosin and lowering the intracellular calcium level. Albuterol sulfate can also be used to treat acute hyperkalemia of the blood.

용도Albuterol Sulfate belongs to a class of bronchodilator drugs called β2-adrenoceptor agonists. It is a prescription medicine used to treat symptoms of bronchospasm. Albuterol Sulfate may be used alone or with other medications.

일반 설명Albuterol belongs to the class of medicines known as bronchodilators. It is also called a short-acting beta-agonist (SABA).