Salbutamol Sulfate → Salbutamol

HRID 333510

반응식

HRID 333510 반응식
[CH3:1][C:2]([NH:5][CH2:6][CH:7]([OH:17])[C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:14][OH:15])[CH:13]=1)([CH3:4])[CH3:3].OS(O)(=O)=O>O>[CH3:4][C:2]([NH:5][CH2:6][CH:7]([OH:17])[C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:14][OH:15])[CH:13]=1)([CH3:1])[CH3:3]

참가 물질

3

반응물 1

HCID 9884233Salbutamol Sulfate

생성물 1

HCID 2083Salbutamol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

The Albuterol Resin Complex was prepared by first dissolving 286 g of albuterol sulfate in 8 liters of purified water, and then slowly adding 1837 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 30%. KOLLICOAT™ SR-30D of 640 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried at 50° C. in a VWR™ convection oven to the moisture content around 25%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

후처리

  1. additionslowly adding 1837 g of AMBERLITE™
  2. additionThe dispersion was mixed for 4 hours and upon completion
  3. custombefore decanting the supernatant
  4. customThe wet resin complex was then dried in a VWR™ convection oven
  5. additionKOLLICOAT™ SR-30D of 640 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
  6. customto form a uniform mass
  7. customThe wet mass was again dried at 50° C. in a VWR™ convection oven to the moisture content around 25%
  8. customThe semi-dried granules were then milled through a 40 mesh screen
  9. customcontinued drying under 50° C. until the moisture content
  10. customThe dried granules were then milled through a 40 mesh screen

출처 및 근거

ORD 기록
ord-23bdf365fe24482391a0dfbc44ab6434
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883217B2

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