Hydrochloric Acid → 2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide hydrochloride

HRID 1003288노트

반응식

HRID 1003288 반응식
[OH:1][C@H:2]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[CH2:3][NH:4][C@H:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:15][CH2:16][C:17]([N:19]([CH3:21])[CH3:20])=[O:18])=[CH:10][CH:11]=2)[CH2:6]1.[ClH:29]>C(O)C>[ClH:29].[OH:1][C@H:2]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[CH2:3][NH:4][C@H:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:15][CH2:16][C:17]([N:19]([CH3:20])[CH3:21])=[O:18])=[CH:10][CH:11]=2)[CH2:6]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 98214472-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

생성물 1

HCID 104548412-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-[(2S)-2-[[(2R)-2-Hydroxy-2-(4-hydroxy-phenyl)ethyl]-amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide (210 mg) was suspended in ethanol (10.5 ml), and 1N hydrochloric acid (546 μl) was added to the suspension and the mixture was dissolved by heating. After cooling, collection by filtration of the precipitated crystals gave 2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide hydrochloride (100 mg) having a melting point of 165-168° C.

후처리

  1. dissolutionthe mixture was dissolved
  2. temperatureby heating
  3. temperatureAfter cooling
  4. customcollection
  5. filtrationby filtration of the precipitated crystals

출처 및 근거

ORD 기록
ord-25737600d3714beab167194fc2637fbe
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046192

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