Chloroform → 12-Iodododecylamine hydroiodide

HRID 1003307노트

반응식

HRID 1003307 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]O.C(Cl)(Cl)Cl.[IH:19]>>[IH:19].[I:19][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]

참가 물질

4

반응물 3

HCID 6212ChloroformHCID 24841Hydrogen iodideHCID 518202012-Amino-1-dodecanol

생성물 1

HCID 1879642712-Iodododecylamine hydroiodide

실험 절차

An aqueous solution of 100 mg of 12-aminododecanol in 57% hydriodic acid was heated under reflux for one hour. To the reaction solution was added chloroform and the mixture was washed successively with water, a 10% aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off and the residue thus obtained was chromatographed over a silica gel column to afford 171 mg of the title compound.

후처리

  1. temperatureunder reflux for one hour
  2. washthe mixture was washed successively with water
  3. dry with materiala 10% aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off
  5. customthe residue thus obtained
  6. customwas chromatographed over a silica gel column

출처 및 근거

ORD 기록
ord-8c38f6e4b61b4f4e9b472ebd6d0b9738
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046201

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