Hydrochloric Acid → 12-Iodododecylamine hydrochloride

HRID 1003314노트

반응식

HRID 1003314 반응식
[I:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[I:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 1879643112-(Boc-amino)-1-dodecyl iodine

생성물 1

HCID 1879643312-Iodododecylamine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 0.33 g of tert-butyl N-(12-iodododecyl)carbamate in 25 ml of ethyl acetate was added 2.6 ml of hydrochloric acid and the mixture was stirred for 0.5 hour. The reaction solution was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Crystallization from ethyl acetate and hexane afforded 0.17 g of the title compound.

후처리

  1. distillationThe reaction solution was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure
  6. customCrystallization from ethyl acetate and hexane

출처 및 근거

ORD 기록
ord-9d8086cb726c47e79befbdda465bcca0
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046201

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