Sulfuric Acid → 3-Chloro-4-acetoxybenzoic acid

HRID 1003355

반응식

HRID 1003355 반응식
O.[Cl:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[OH:12])[C:6]([OH:8])=[O:7].ClC1C=[C:16](C=CC=1O)[C:17](O)=[O:18].S(=O)(=O)(O)O>C(OC(=O)C)(=O)C>[C:17]([O:12][C:11]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[Cl:2])(=[O:18])[CH3:16]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 27236113-Chloro-4-hydroxybenzoic acid hemihydrate

생성물 1

HCID 106562963-Chloro-4-acetoxybenzoic acid수율 75%

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

반응 조건

온도
100 °C

실험 절차

3-Chloro-4-hydroxybenzoic acid hemihydrate (10.16 g, 56 mmol) was dissolved in 20 ml of acetic anhydride, followed by the addition of 0.5 ml of concentrated sulfuric acid. The resulting mixture was stirred at 100° C. for 3 hours and was then allowed to stand overnight at room temperature. The precipitate was collected by filtration and then washed with benzene, whereby 8.95 g of 4-acetoxy-3-chlorobenzoic acid were obtained (yield: 75%, melting point: 149-151° C.). A mixture of 8.95 g (41.7 mmol) of 4-acetoxy-3-chlorobenzoic acid and 22.23 g (167 mmol) of aluminum chloride was then heated at 180° C. for 3 hours. Subsequent to the addition of ice and 1N hydrochloric acid, the resultant mixture was extracted with ethyl acetate. The organic layer was washed with water and was then dried over MgSO4. The solvent was distilled off under reduced pressure and the residue was recrystallized from ethyl acetate, whereby 2.97 g of the title compound were obtained as yellow powder (yield: 33%).

후처리

  1. waitto stand overnight at room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with benzene

출처 및 근거

ORD 기록
ord-4743a01007e14990be8d0b7dc4a33db6
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046212

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