4-Ethoxybenzaldehyde → alpha-(4-Ethoxyphenyl)-N-tert-octylnitrone

HRID 1003679

반응식

HRID 1003679 반응식
C(OC1C=CC([NH:10][C:11]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:12])=CC=1)C.ClC1C=C(C=CC=1)C(OO)=[O:24].[BH4-].[Na+].[CH2:32]([O:34][C:35]1[CH:42]=[CH:41][C:38]([CH:39]=O)=[CH:37][CH:36]=1)[CH3:33].C(N)(CC(C)(C)C)(C)C>C(Cl)Cl.CO>[CH2:32]([O:34][C:35]1[CH:42]=[CH:41][C:38]([CH:39]=[N+:10]([C:11]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:12])[O-:24])=[CH:37][CH:36]=1)[CH3:33]

참가 물질

8

반응물 5

HCID 248344-EthoxybenzaldehydeHCID 61017tert-OctylamineHCID 70297m-Chloroperbenzoic acidHCID 4311764Sodium borohydrideHCID 18433750HCID 18433750, 화합물

생성물 1

HCID 86587909alpha-(4-Ethoxyphenyl)-N-tert-octylnitrone

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared by oxidation of N-(4-ethoxyphenyl)-N-tert-octylamine with m-chloroperoxybenzoic acid in methylene chloride. The amine was synthesized via NaBH4 reduction from the corresponding imine which was acquired by condensation of 4-ethoxybenzaldehyde and tert-octylamine in methanol. The title compound was isolated in 65.0% overall yield as white crystals, m.p. 100.8° C. (Rf =0.33 on silica gel plate using hexanes:EtOAc, 7:3, v/v, as an eluant).

출처 및 근거

ORD 기록
ord-c68146c80b7f4da5872fd5316ca2ac09
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046232

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