Hydrochloric Acid → HCID 54052828, 화합물

HRID 1003744노트

반응식

HRID 1003744 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[F:18])[CH2:5][C:6]1[O:10]C=[N:8][C:7]=1[C:11]([O:13][CH3:14])=[O:12].Cl>CO>[CH3:14][O:13][C:11](=[O:12])[CH:7]([NH2:8])[C:6](=[O:10])[CH2:5][C:4]1[CH:15]=[CH:16][C:17]([F:18])=[C:2]([F:1])[CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 18798270HCID 18798270, 화합물

생성물 1

HCID 54052828HCID 54052828, 화합물수율 104.6%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

To 5-(3,4-difluorobenzyl)-4-methoxycarbonyloxazole (0.100 g, 0.393 mmol) in methanol (5 mL) was added 2 mL of 6N HCl, and the solution heated at 80° C. for 2 hours. The reaction mixture was concentrated to yield 0.100 g (88%) of a solid which was used as such for the subsequent step.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-9b7c10a22e814ef88e89d6b933f93a39
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046331

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