Hydrogen Bromide → 5-Iodobenzene-1,3-diol

HRID 1003945

반응식

HRID 1003945 반응식
C[O:2][C:3]1[CH:4]=[C:5]([I:11])[CH:6]=[C:7]([O:9]C)[CH:8]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([I:11])[CH:6]=[C:7]([OH:9])[CH:8]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 6401791-Iodo-3,5-dimethoxybenzene

생성물 1

HCID 6167555-Iodobenzene-1,3-diol수율 99.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3,5-Dimethoxyiodobenzene (1.19 g) is dissolved in acetic acid (10 ml), and thereto is added 47% hydrobromic acid (10 ml) at room temperature, and the mixture is refluxed for 15 hours. The reaction mixture is cooled to room temperature, and concentrated to dryness under reduced pressure. The residue is dissolved in ethyl acetate, and the organic layer is washed with water, dried, and concentrated under reduced pressure to give 3,5-dihydroxyiodobenzene (1.06 g).

후처리

  1. temperaturethe mixture is refluxed for 15 hours
  2. concentrationconcentrated to dryness under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washthe organic layer is washed with water
  5. customdried
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-82fa8e9a43cd431faf20c55195195adb
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048842

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