Hydrogen Bromide → 5-Ethylbenzene-1,3-diol

HRID 1003950노트

반응식

HRID 1003950 반응식
C[O:2][C:3]1[CH:8]=[C:7]([CH2:9][CH3:10])[CH:6]=[C:5]([O:11]C)[CH:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:8]=[C:7]([CH2:9][CH3:10])[CH:6]=[C:5]([OH:11])[CH:4]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 524877Benzene, 1,3-dimethoxy-5-ethyl

생성물 1

HCID 127958985-Ethylbenzene-1,3-diol수율 92.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

1,3-Dimethoxy-5-ethylbenzene (7.69 g) is dissolved in acetic acid (80 ml), and thereto is added with stirring 47% hydrobromic acid at room temperature. The mixture is refluxed for three hours, and the reaction mixture is cooled to room temperature. The mixture is concentrated to dryness under reduced pressure, and the residue is dissolved in ethyl acetate. The organic layer is washed successively with water and a saturated aqueous sodium chloride solution, dried, and concentrated under reduced pressure. The residue is recrystallized from diisopropyl ether-hexane to give 1,3-dihydroxy-5-ethylbenzene (5.94 g), m.p. 97-98° C.

후처리

  1. additionis added
  2. temperatureThe mixture is refluxed for three hours
  3. concentrationThe mixture is concentrated to dryness under reduced pressure
  4. dissolutionthe residue is dissolved in ethyl acetate
  5. washThe organic layer is washed successively with water
  6. dry with materiala saturated aqueous sodium chloride solution, dried
  7. concentrationconcentrated under reduced pressure
  8. customThe residue is recrystallized from diisopropyl ether-hexane

출처 및 근거

ORD 기록
ord-d254cc20ae57415d9e2941cf46b040f9
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048842

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