Acetic Anhydride → HCID 15816962, 화합물
반응식
[CH3:1][C:2]1[NH:16][CH2:15][CH2:14][C:4]2=[C:5]3[C:10](=[N:11][C:3]=12)[CH:9]=[CH:8][C:7]([O:12][CH3:13])=[CH:6]3.[C:17](OC(=O)C)(=[O:19])[CH3:18].C(OCC)(=O)C>N1C=CC=CC=1>[CH2:1]=[C:2]1[C:3]2[NH:11][C:10]3[C:5](=[CH:6][C:7]([O:12][CH3:13])=[CH:8][CH:9]=3)[C:4]=2[CH2:14][CH2:15][N:16]1[C:17](=[O:19])[CH3:18]참가 물질
5
실험 절차
To a solution of 10-methoxyharmalan (1 mmol) in pyridine (2 ml) is added acetic anhydride (1.1 eq) . After acid hydrolysis and extraction with ethyl acetate, the crude product is flash-chromatographed (eluent: EtOAc/pet. ether; 50/50). The 1-methylene-2-acetyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline elutes off first.
후처리
- customthe crude product is flash-chromatographed (eluent: EtOAc/pet. ether; 50/50)
출처 및 근거
- ORD 기록
- ord-895b5cbf72bf41449642c4b4c5758390
- 출처 데이터셋
- uspto-grants-2000_04
- 특허 번호
- US06048868
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