Propanal → HCID 54570890, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH2:18][C@H:19]([OH:28])[CH2:20][O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:4][CH:3]=1.[CH:29](=O)[CH2:30][CH3:31]>>[OH:28][C@H:19]([CH2:20][O:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:18][N:10]([CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][CH2:29][CH2:30][CH3:31])=[CH:3][CH:4]=1)[C:11](=[O:17])[O:12][C:13]([CH3:14])([CH3:16])[CH3:15]

참가 물질

반응물 2

HCID 527Propanal

HCID 54547220HCID 54547220, 화합물

생성물 1

HCID 54570890HCID 54570890, 화합물수율 100.3%

실험 절차

1.52 g of t-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxypropyl)carbamate and 0.23 g of propionaldehyde were subjected to a reductive amination reaction to obtain 1.69 g of t-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-(4-propylaminophenyl)ethyl]carbamate.

출처 및 근거

ORD 기록: ord-af44f1fb76b94324adad37ce5bf75dc4
출처 데이터셋: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06048884

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