Hydrochloric Acid → 5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoic acid hydrochloride
반응식
C[O:2][C:3](=[O:18])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:17]=[CH:16][C:15]2[CH2:14][CH2:13][CH2:12][NH:11][C:10]=2[N:9]=1.[ClH:19]>>[ClH:19].[N:9]1[C:10]2[NH:11][CH2:12][CH2:13][CH2:14][C:15]=2[CH:16]=[CH:17][C:8]=1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:18])=[O:2]참가 물질
3
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of 1-5 (620 mg, 2.50 mmol) and 6N HCl (12 mL) was heated at 50° C. for 18 h. Evaporative removal of the solvent gave 1-6 as a yellow solid.
후처리
- customEvaporative removal of the solvent
출처 및 근거
- ORD 기록
- ord-87a1cf046771484dac00710e1cf58936
- 출처 데이터셋
- uspto-grants-2000_04
- 특허 번호
- US06048861
반응 노트
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