Methanol → Methyl (2-chlorophenyl)acetate

HRID 1004306

반응식

HRID 1004306 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]

참가 물질

4

반응물 2

HCID 887MethanolHCID 17124o-Chlorophenylacetic acid

생성물 1

HCID 93683Methyl (2-chlorophenyl)acetate

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

A solution of 2-chlorophenylacetic acid (10.0 g) in methanol (100 ml) containing 1 drop of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was evaporated to half volume and partitioned between ethyl acetate (100 ml) and water (100 ml). The organic phase was dried over magnesium sulphate and evaporated to give the title compound (10.0 g) as a colourless oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. customThe reaction mixture was evaporated to half volume
  4. custompartitioned between ethyl acetate (100 ml) and water (100 ml)
  5. dry with materialThe organic phase was dried over magnesium sulphate
  6. customevaporated

출처 및 근거

ORD 기록
ord-9fca659e73f847a3a5eb5a0804ca6a53
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048893

연결된 노트

불러오는 중…