Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4'-Bromo-4-carboxymethylbiphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 1-(4'-Bromo(1,1'-biphenyl)-4-yl)ethan-1-one | HCID 79806 | — |
| 반응물 | Sulfur | HCID 5362487 | — |
| 생성물 | 4'-Bromo-4-carboxymethylbiphenyl | HCID 1394245 | — |
반응 단계
The compound (3 g) obtained in the above (1) is suspended in morpholine (20 ml), and thereto is added sulfur (0.71 g), and the mixture is refluxed with stirring for five hours. After cooling, the reaction mixture is poured into water, and extracted with ethyl acetate. The organic layer is washed with 1N hydrochloric acid (twice) and a saturated brine (twice), and dried over anhydrous sodium sulfate. The desiccant is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is suspended in ethanol, and the precipitates are collected by filtration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06048854 |
| 출처 데이터셋 | uspto-grants-2000_04 |
| ORD ID | ord-78e0cf40f386481aa4f06f0069be9b7d |
| 출처 메모 | uspto-grants-2000_04 |