2-amino-4-phenyl-1H-pyrrole-3-carbonitrile → 5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 1004604노트

반응식

HRID 1004604 반응식
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][C:11](OC)=[CH:10][CH:9]=2)=[CH:6][NH:5][C:4]=1[NH:16][CH:17]=[NH:18])#[N:2].NC1NC=C(C2C=CC=CC=2)C=1C#N>C(OCC)(OCC)OCC>[C:8]1([C:7]2[C:3]3[C:1]([NH2:2])=[N:18][CH:17]=[N:16][C:4]=3[NH:5][CH:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 27668732-amino-4-phenyl-1H-pyrrole-3-carbonitrileHCID 178488786HCID 178488786, 화합물

생성물 1

HCID 53577645-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

시약·촉매·용매 1

HCID 31214Ethyl orthoformate용매

반응 조건

온도
140 °C

실험 절차

N-[3-Cyano-4-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-formamidine: 6.0 g of 2-amino-4-phenyl-1H-pyrrole-3-carbonitrile are dissolved in 80 ml of triethyl orthoformate, and the solution is stirred for 1 hour at 140° C. The triethyl orthoformate is removed under a high vacuum and the residue is dissolved in methanol saturated with ammonia. Stirring is carried out for 24 hours at room temperature, followed by filtration. The product is recrystallised from ethanol. M.p.: 238-239° C.

후처리

  1. customThe triethyl orthoformate is removed under a high vacuum
  2. dissolutionthe residue is dissolved in methanol saturated with ammonia
  3. stirringStirring
  4. waitis carried out for 24 hours at room temperature
  5. filtrationfollowed by filtration
  6. customThe product is recrystallised from ethanol

출처 및 근거

ORD 기록
ord-21eb41dcca5947c69200a28d2ddf9277
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06051577

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