2-Amino-4-(3-methoxyphenyl)-1H-pyrrole-3-carbonitrile → HCID 18792871, 화합물

HRID 1004605노트

반응식

HRID 1004605 반응식
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)=[CH:6][NH:5][C:4]=1[NH:16][CH:17]=[NH:18])#[N:2].NC1NC=C(C2C=CC=C(OC)C=2)C=1C#N>C(OCC)(OCC)OCC>[CH3:15][O:14][C:10]1[CH:9]=[C:8]([C:7]2[C:3]3[C:1]([NH2:2])=[N:18][CH:17]=[N:16][C:4]=3[NH:5][CH:6]=2)[CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 187929202-Amino-4-(3-methoxyphenyl)-1H-pyrrole-3-carbonitrileHCID 178489845HCID 178489845, 화합물

생성물 1

HCID 18792871HCID 18792871, 화합물

시약·촉매·용매 1

HCID 31214Ethyl orthoformate용매

반응 조건

온도
140 °C

실험 절차

N-[3-Cyano-4-(3-methoxy-phenyl)-1H-pyrrol-2-yl]formamidine: 5.30 g of 2-amino4-(3-methoxy-phenyl)-1H-pyrrole-3-carbonitrile are dissolved in 50 ml of triethyl orthoformate, and the solution is stirred for 1 hour at 140° C. The triethyl orthoformate is removed under a high vacuum and the residue is dissolved in methanol saturated with ammonia. Stirring is carried out for 20 hours at room temperature, followed by filtration. The product is recrystallised from ethanol. M.p.: 188-190° C.

후처리

  1. customThe triethyl orthoformate is removed under a high vacuum
  2. dissolutionthe residue is dissolved in methanol saturated with ammonia
  3. stirringStirring
  4. waitis carried out for 20 hours at room temperature
  5. filtrationfollowed by filtration
  6. customThe product is recrystallised from ethanol

출처 및 근거

ORD 기록
ord-85c73a0a5b7743778a37065400de14ab
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06051577

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