Sodium borohydride → 4-Cyclopentylbutan-1-ol

HRID 1004645노트

반응식

HRID 1004645 반응식
[CH:1]1([CH2:6][CH2:7][CH2:8][CH:9]=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+]>C(O)C>[CH:1]1([CH2:6][CH2:7][CH2:8][CH2:9][OH:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 219320564-Cyclopentylbutanal

생성물 1

HCID 217976434-Cyclopentylbutan-1-ol수율 63%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Cyclopentyl-butyraldehyde (4.9 g, 35 mmol) was taken up in ethanol (100 mL) and treated slowly with sodium borohydride (1.72 g, 4.54 mmol). The reaction was stirred for three days and quenched with water (10 mL). The reaction was diluted with dichloromethane (200 mL) and washed with water (2×100 mL). The organic phase was dried (MgSO4), filtered, and concentrated to yield an oil. The product was passed through a pad of silica to yield 4-cyclopentyl-butan-1-ol as a colorless oil (3.12 g, 63%).

후처리

  1. customquenched with water (10 mL)
  2. additionThe reaction was diluted with dichloromethane (200 mL)
  3. washwashed with water (2×100 mL)
  4. dry with materialThe organic phase was dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto yield an oil

출처 및 근거

ORD 기록
ord-1612288e8b024818bf4af09b0642a0cc
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06051586

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