1,1-Dibutoxycyclohexane → 2-[(1-Butoxycyclohexyloxy)methyl]-5-(3,5-dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazole
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][OH:17])=[N:12][C:11]=2[CH:18]([CH3:20])[CH3:19])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:21]([O:25][C:26]1(OCCCC)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[CH2:22][CH2:23][CH3:24]>>[CH2:21]([O:25][C:26]1([O:17][CH2:16][C:13]2[N:14]([CH3:15])[C:10]([S:9][C:4]3[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=3)=[C:11]([CH:18]([CH3:20])[CH3:19])[N:12]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[CH2:22][CH2:23][CH3:24]참가 물질
3
실험 절차
The compound 14 (3.1 mg, 0.1 mmol) was converted to the acetal with 1,1-dibutoxycyclohexane (228 mg, 1 mmol) in the same manner as the example 14 to give the compound 16 (15 mg, 30%) as oil. Rf 0.44 (Al2O3 60, Type E, toluene).
출처 및 근거
- ORD 기록
- ord-b2ab2a707f264b7a858f4e433d52e597
- 출처 데이터셋
- uspto-grants-2000_04