1,1-Dibutoxycyclohexane → 2-(1-Butoxycyclohexyloxy)methyl-5-(3,5-dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazole

HRID 1005520

반응식

HRID 1005520 반응식
[OH:1][CH2:2][C:3]1[N:4]([CH2:20][CH3:21])[C:5]([S:11][C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.[CH2:22]([O:26][C:27]1(OCCCC)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:23][CH2:24][CH3:25]>>[CH2:22]([O:26][C:27]1([O:1][CH2:2][C:3]2[N:4]([CH2:20][CH3:21])[C:5]([S:11][C:12]3[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=3)=[C:6]([CH:8]([CH3:9])[CH3:10])[N:7]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:23][CH2:24][CH3:25]

참가 물질

3

반응물 2

HCID 2437181,1-DibutoxycyclohexaneHCID 473933(5-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-yl)methanol

생성물 1

HCID 187920522-(1-Butoxycyclohexyloxy)methyl-5-(3,5-dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazole수율 35%

실험 절차

The compound 19 (345 mg, 1.00 mmol) was converted to the acetal with 1,1-dibutoxycyclohexane (2.28 g, 10.0 mmol) in the same manner as the example 18 to give the compound 21 (172 mg, 35%) as oil. Rf 0.41 (Al2O3 60, Type E, toluene).

출처 및 근거

ORD 기록
ord-b97b14f4d45547458ad5b9ca3ec6d6e1
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06054591

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