Potassium Carbonate → 1-Chloroisoquinolin-6-amine

HRID 1005679노트

반응식

HRID 1005679 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([NH:12]S(C3C=CC(C)=CC=3)(=O)=O)=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>S(=O)(=O)(O)O>[NH2:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([Cl:1])=[N:3][CH:4]=[CH:5]2

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 22674092HCID 22674092, 화합물

생성물 1

HCID 226741141-Chloroisoquinolin-6-amine수율 76.81%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

In sulfuric acid (30 ml) was dissolved 3.323 g of 1-chloro-6-(4-toluenesulfonylamino)isoquinoline (Preparation Example 22), followed by stirring at room temperature overnight. The reaction mixture was poured onto ice, and basified by adding an aqueous sodium hydroxide and then potassium carbonate, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (1.37 g, 76.81%) as yellowish brown crystals.

후처리

  1. additionThe reaction mixture was poured onto ice
  2. extractionby extracting with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-8927afb08bf3404085eb186010fdaf96
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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