Water → N-Acetyl-N-(3-aminophenethyl)amine

HRID 1005683노트

반응식

HRID 1005683 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[CH:8]=1)(=[O:3])[CH3:2].C([O-])(=O)C.[NH4+].O>C(O)C.[Fe]>[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH2:13])[CH:8]=1)(=[O:3])[CH3:2]

참가 물질

6

반응물 3

HCID 962WaterHCID 517165Ammonium AcetateHCID 22674066N-(3-Nitrophenethyl)acetamide

생성물 1

HCID 22674097N-Acetyl-N-(3-aminophenethyl)amine수율 96%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 702Ethanol용매

실험 절차

In ethanol (40 ml) was dissolved 2.1 g of N-acetyl-N-(3-nitrophenethyl)amine (Preparation Example 28), and powdered iron (2.25 g), ammonium acetate (4.3 g) and water (20 ml) were added thereto, followed by heating under reflux for 1.5 hours. The solid matter was filtered off and washed with ethanol, and a part of the filtrate was evaporated. The residue was extracted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (1.723 g, 96%) as a yellow oil.

후처리

  1. additionwere added
  2. temperatureby heating
  3. temperatureunder reflux for 1.5 hours
  4. filtrationThe solid matter was filtered off
  5. washwashed with ethanol
  6. customa part of the filtrate was evaporated
  7. extractionThe residue was extracted with ethyl acetate
  8. washwashed with brine
  9. dry with materialdried over anhydrous magnesium sulfate
  10. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-49e02630b8ae4d999313e885843b385c
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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